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作 者:刘晓玲 金宇 LIU Xiao-ling;JIN Yu(Department of Laboratory,the Second Affiliated Hospital of Chengdu Medical College,China National Nuclear Corporation 416 Hospital,Chengdu 610051,Sichuan,China)
机构地区:[1]成都医学院第二附属医院•核工业四一六医院检验科,四川成都610051
出 处:《川北医学院学报》2024年第11期1495-1498,共4页Journal of North Sichuan Medical College
基 金:四川省科技计划项目(2018JY0372)。
摘 要:目的:检测肝癌患者血清热休克蛋白90α(HSP90α)、胸苷激酶1(TK1)水平,分析其对肝癌的诊断价值。方法:纳入确诊肝癌患者为肝癌组(n=82);另纳入同期确诊良性肝病患者为对照组(n=82)。采用酶联免疫吸附法检测两组血清HSP90α、TK1水平并进行比较,联合临床病理分析血清HSP90α、TK1水平和病理特征的关系。采用受试者工作特征(ROC)曲线评价各指标对肝癌的诊断价值。结果:肝癌组患者血清HSP90α、TK1水平均高于良性肝病组患者(P<0.05);肝外转移、TNM分期为Ⅲ~Ⅳ的肝癌患者血清HSP90α、TK1水平均较高(P<0.05)。ROC曲线结果显示,血清HSP90α、TK1均对肝癌有一定的诊断价值(P<0.05),且联合检测诊断肝癌的曲线下面积(AUC)为0.921,高于各指标单独检测(P<0.05)。结论:肝癌患者血清HSP90α、TK1水平升高,且与病情的发生、发展有一定的关联,两项指标联合检测诊断肝癌的价值更高。Objective:To detect levels of serum heat shock protein 90α(HSP90α)and thymidine kinase 1(TK1),and to analyze their diagnostic value in patients with liver cancer.Methods:A total of 82 patients with liver cancer and 82 patients with benign liver diseases were enrolled as liver cancer group and benign liver disease group,respectively.The levels of serum HSP90αand TK1 were detected by enzyme-linked immunosorbent assay and compared between the two groups.The relationship between serum HSP90α,TK1 and pathological characteristics was analyzed by clinicopathological analysis.The diagnostic value of HSP90αand TK1 for liver cancer was evaluated by ROC curves.Results:The levels of serum HSP90αand TK1 in liver cancer group were higher than those in benign liver disease group(P<0.05).The levels of serum HSP90αand TK1 were higher in patients with extrahepatic metastasis and TNM staging at stageⅢ~Ⅳ(P<0.05).The results of ROC curves analysis showed that serum HSP90αand TK1 were of certain diagnostic value in liver cancer(P<0.05),AUC of combined detection(parallel mode)was 0.921,greater than that of single index(P<0.05).Conclusion:The levels of serum HSP90αand TK1 are increased in patients with liver cancer,which are correlated with the occurrence and development of the disease.Combined detection of the two indexes has higher diagnostic value in liver cancer.
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