甲硝唑冲洗辅助断冠再接术对恒前牙外伤性折断患者的应用效果及对龈沟液炎症因子的影响  

Application of metronidazole irrigation-assisted broken crown reattachment on patients with traumatic fractures of permanent anterior teeth and influence on gingival crevicular fluid inflammatory factors

作　　者：高朵朵 呼海燕[2] 拓瑞 黄威[4] 高志彪[3] GAO Duo-duo;HU Hai-yan;TA Rui;HUANG Wei;GAO Zhi-biao(Department of Periodontology,Yan’an University Affiliated Hospital,Yan'an 716000,Shaanxi;Department of Prosthodontics,Yan’an University Affiliated Hospital,Yan'an 716000,Shaanxi;Department of Oral and Maxillofacial Surgery,Yan’an University Affiliated Hospital,Yan'an 716000,Shaanxi;Department of Oral and Maxillofacial Surgery,Hospital of Stomatology,Hebei Medical University,Shijiazhuang 050000,Hebei,China)

机构地区：[1]延安大学附属医院牙周病科,陕西延安716000 [2]延安大学附属医院口腔修复科,陕西延安716000 [3]延安大学附属医院口腔颌面外科,陕西延安716000 [4]河北医科大学口腔医院口腔颌面外科,河北石家庄050000

出　　处：《川北医学院学报》2024年第11期1503-1506,共4页Journal of North Sichuan Medical College

基　　金：河北省重点研发计划项目(20377747D)。

摘　　要：目的:探讨甲硝唑冲洗辅助断冠再接术对恒前牙外伤性折断患者的应用效果及对龈沟液炎症因子的影响。方法:选取84例行活髓切断术+断冠再接术治疗的恒前牙外伤性折断患者为研究对象,依据使用辅助治疗方式不同分为观察组(n=43)和对照组(n=41)。观察组患者行甲硝唑冲洗辅助治疗;对照组行生理盐水冲洗辅助治疗。比较两组患者治疗成功率;术后1、4、12周口腔卫生情况[牙菌斑指数(PLI)、牙龈指数(GI)];龈沟液炎症因子[Ⅱ型胶原(COL-Ⅱ)、白细胞介素8(IL-8)、碱性磷酸酶(ALP)]水平;疼痛程度[视觉模拟评分法(VAS)评分]。结果:两组患者患者治疗成功率比较,差异无统计学意义(100.00%vs.97.56%,P>0.05)。术后1、4周,观察组患者PLI、GI指数及龈沟液COL-Ⅱ、IL-8、ALP和VAS评分低于对照组(P<0.05)。结论:甲硝唑冲洗辅助活髓切断术+断冠再接术,可减轻恒前牙外伤性冠折患者术后牙龈炎症,改善口腔卫生,对减轻术后疼痛有积极作用。Objective:To analyze the application effect of metronidazole irrigation-assisted broken crown reattachment on patients with traumatic fractures of permanent anterior teeth and its influence on gingival crevicular fluid inflammatory factors.Methods:84 patients with traumatic fractures of permanent anterior teeth who underwent vital pulpotomy+broken crown reattachment were divided into observation group(43 cases,metronidazole irrigation)and control group(41 cases,normal saline irrigation)by the different adjuvant therapy methods.The treatment success rate in the two groups was recorded,and the differences in oral health[plaque index(PLI),gingival index(GI)],levels of gingival crevicular fluid typeⅡcollagen(COL-Ⅱ),interleukin 8(IL-8)and alkaline phosphatase(ALP)and pain degree[Visual Analogue Scale(VAS)score]were compared at 1,4 and 12 weeks after broken crown reattachment.Results:The success rates of treatment in observation group and control group were 100.00%(43/43)and 97.56%(40/41),respectively,without a statistical significance(P>0.05).The PLI,GI,and gingival crevicle fluid COL-Ⅱ,IL-8,ALP,VAS scores in observation group at 1 week after surgery and at 4 weeks after surgery were lower than in control group,with statistical differences(P<0.05).Conclusion:Metronidazole irrigation-assisted vital pulpotomy+broken crown reattachment can relieve the postoperative gingival inflammation and improve the oral hygiene in patients with traumatic crown fractures of permanent anterior teeth,and it plays a positive role on reducing postoperative pain.

关 键 词：牙外伤 恒前牙 断冠再接术 甲硝唑冲洗治疗 口腔卫生 龈沟液 

分 类 号：R788.4[医药卫生—口腔医学]