代谢综合征各组分与结肠腺瘤性息肉相关性的研究进展  

Research progress on the correlation between metabolic syndrome components and colonic adenomatous polyps

作　　者：刘佩(综述) 郑盛 杨涓(审校) LIU Pei;ZHENG Sheng;YANG Juan(School of Clinical Medicine,Dali University,Dali,Yunnan 671003,China;The Second Affiliated Hospital of Dali University,Kunming,Yunnan 650011,China)

机构地区：[1]大理大学临床医学院,云南大理671003 [2]大理大学第二附属医院,云南昆明650011

出　　处：《现代医药卫生》2024年第22期3917-3922,共6页Journal of Modern Medicine & Health

基　　金：云南省地方高校(部分)基础研究联合专项面上项目(202301BA070001-029,202301BA070001-044);云南省高层次科技人才及创新团队选拔专项-中青年学术和技术带头人后备人才项目(202405AC350067)。

摘　　要：结肠腺瘤性息肉是指发生在结肠黏膜的隆起性病变,属于良性肿瘤之一,一般无明显的临床症状,由结直肠镜检查发现,通过活检或切除病理明确诊断。代谢综合征是一组以肥胖、高血糖、高血压、血脂异常为主要特征,严重影响机体健康的临床症候群。目前,多项研究表明代谢综合征与结肠息肉,尤其是腺瘤性息肉关系非常密切,其发病机制可能与胰岛素抵抗、瘦素、脂联素、炎症因子、活性氧等有关。腺瘤性息肉是结肠癌常见的癌前病变,因此,早期筛查并控制结肠腺瘤性息肉发生、发展是一种降低结肠癌发生的有效手段。该文对代谢综合征各组分与结肠腺瘤性息肉相关性研究进展进行了综述。The colonic adenomatous polyp is a bulging lesion that occurs in the colonic mucosa,belonging to one of the benign tumors,usually without obvious clinical symptoms,detected by colorectaloscopy,and definitively diagnosed by biopsy or resection pathology.Metabolic syndrome(MS)is a group of clinical syndromes characterized by obesity,hyperglycemia,hypertension and dyslipidemia,which seriously affect the health of the body.Currently,many studies have shown that metabolic syndrome is closely related to colon polyps,especially adenomatous polyps,and its pathogenesis may be related to insulin resistance,leptin,lipocalin,inflammatory factors,reactive oxygen species,and so on.Adenomatous polyps are common precancerous lesions of colon cancer,therefore,early screening and control of colonic adenomatous polyp occurrence and development is an effective means to reduce the occurrence of colon cancer.This article reviews the progress of research on the correlation between the components of metabolic syndrome and colonic adenomatous polyps.

关 键 词：代谢综合征 结肠腺瘤性息肉 结直肠癌 危险因素 胰岛素抵抗 综述 

分 类 号：R57[医药卫生—消化系统]