肺曲霉病诊断方法的研究进展  

Research progress on diagnostic methods for pulmonary aspergillosis

作　　者：万清清(综述) 彭丽(审校)[1] WAN Qingqing;PENG Li(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of General Medicine,the People's Hospital of Qijiang District in Chongqing,Chongqing 401420,China)

机构地区：[1]重庆医科大学附属第一医院呼吸与危重症医学科,重庆400016 [2]重庆市綦江区人民医院全科医学科,重庆401420

出　　处：《现代医药卫生》2024年第22期3923-3928,3935,共7页Journal of Modern Medicine & Health

基　　金：重庆市科卫联合医学科研项目(2020FYYX191)。

摘　　要：全球每年侵袭性真菌感染人数高达约655万人,并导致约380万人死亡,其中曲霉菌属肺部感染最常见。由于肺曲霉病在临床和影像学表现特异性不明显,传统实验室检测存在不同程度的检测周期长、灵敏度相对较低等局限,下一代测序、曲霉菌聚合酶链反应等分子生物学检测技术较好地弥补了传统诊断技术的不足,分子生物学技术势必会迎来更广泛的应用前景。The number of invasive fungal infections is as high as about 6.55 million people each year in the world,and it leads to about 3.8 million deaths,among which aspergillus pulmonary infection is the most common.Because the specificity of clinical and imaging manifestations of pulmonary aspergillosis is not obvious,traditional laboratory tests have different degrees of limitations such as long detection period and relatively low sensitivity.Molecular biology detection techniques such as next generation sequencing and Aspergillus polymerase chain reaction have made up for the shortcomings of traditional diagnostic techniques.Molecular biology technology is bound to usher in a broader application prospect.

关 键 词：侵袭性曲霉病 半乳甘露聚糖抗原 分子诊断技术 聚合酶链反应 下一代测序 支气管肺泡灌洗液 综述 

分 类 号：R56[医药卫生—呼吸系统]