血清LncRNA KCNQ1OT1和LncRNA MALAT1水平与短暂性脑缺血发作患者颈动脉不稳定斑块形成的关系研究  

Relationship Between Serum LncRNA KCNQ1OT1 and LncRNA MALAT1 Levels and Carotid Unstable Plaque Formation in Patients with Transient Ischemic Attack

作　　者：董小雪 秦建宏 张英[1] 贾俊栋 高莹 房娉平[1] DONG Xiao-xue;QIN Jian-hong;ZHANG Ying;JIA Jun-dong;GAO Ying;FANG Ping-ping(Department of Internal Medicine-Neurology,Hebei Handan Central Hospital of Hebei Province,Handan,Hebei,056000,China)

机构地区：[1]河北省邯郸市中心医院神经内科,河北省邯郸市056000

出　　处：《现代生物医学进展》2024年第19期3682-3684,共3页Progress in Modern Biomedicine

基　　金：河北省重点研发计划项目(21377870D);邯郸市科学技术研究与发展计划项目(2242083081ZC)。

摘　　要：目的:探讨血清长链非编码核糖核酸(LncRNA)钾电压门控通道亚家族Q成员1反链/反义转录物1(KCNQ1OT1)和LncRNA肺腺癌转移相关转录本1(MALAT1)水平与短暂性脑缺血发作(TIA)患者颈动脉不稳定斑块形成的关系。方法:选取2021年1月~2023年1月我院收治的117例TIA患者,根据不稳定颈动脉斑块形成情况分为形成组、未形成组,分别为57例、60例。比较两组患者血清LncRNA KCNQ1OT1和LncRNA MALAT1水平和其他临床资料。通过多因素Logistic回归分析TIA患者颈动脉不稳定斑块形成的影响因素。结果:形成组患者吸烟史、饮酒史、高血压占比和血清LncRNA KCNQ1OT1、LncRNA MALAT1水平高于未形成组(P<0.05)。多因素Logistic回归分析显示,吸烟史、饮酒史和血清LncRNA KCNQ1OT1、LncRNA MALAT1水平是TIA患者颈动脉不稳定斑块形成的独立危险因素(P<0.05)。结论:血清LncRNA KCNQ1OT1和LncRNA MALAT1水平在颈动脉不稳定斑块形成的TIA患者中异常升高,是TIA患者颈动脉不稳定斑块形成的独立危险因素。Objective:To investigate the relationship between serum long non-coding ribonucleic acid(LncRNA)potassium voltage-gated channel subfamily Q member 1 antisense/antisense transcript 1(KCNQ1OT1)and LncRNA lung adenocarcinoma metastasis-associated transcript 1(MALAT1)levels and carotid unstable plaquein formation in patients with transient ischemic attack(TIA).Methods:A total of 117 TIA patients admitted to our hospital from January 2021 to January 2023 were selected,according to the formation of unstable carotid plaque,they were divided into formed and unformed groups,57 and 60 cases,respectively.Serum LncRNA KCNQ1OT1 and LncRNA MALAT1 levels and other clinical data were compared between both groups.The influencing factors of carotid artery unstable plaque formation in TIA patients were analyzed by multivariate Logistic regression.Results:The history of smoking,history of drinking,proportion of hypertension and serum LncRNA KCNQ1OT1 and LncRNA MALAT1 levels in formed group were higher than those of the unformed group(P<0.05).Multivariate Logistic regression analysis showed that history of smoking,history of drinking,serum LncRNA KCNQIOT1 and LncRNA MALAT1 levels were independent risk factors for carotid unstable carotid plaque formation in patients with TIA(P<0.05).Conclusion:The levels of serum LncRNA KCNQ1OT1 and LncRNA MALAT1 are abnormally high in TIA patients with unstable carotid plaques,and they are independent risk factors for the formation of unstable carotid plaques in TIA patients.

关 键 词：短暂性脑缺血发作 LncRNA KCNQ1OT1 LncRNA MALAT1 不稳定斑块 

分 类 号：R743[医药卫生—神经病学与精神病学]