血清CCN1、CCN2与糖尿病视网膜病变患者微血管损伤的关系研究  

Study on the Relationship between Serum CCN1, CCN2 and MicrovascularInjury in Patients with Diabetes Retinopathy

作　　者：李盈 徐建乐 季方正 陈延云 季强 LI Ying;XU Jian-le;JI Fang-zheng;CHEN Yan-yun;JI Qiang(Telemedicine Center,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Ji'nan,Shandong,250021,China;Department of Medical Record Management,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Ji'nan,Shandong,250021,China;Department of Ophthalmology,Ji'nan Central Hospital Affiliated to Shandong First Medical University,Ji'nan,Shandong,250013,China;Department of Clinical Medicine,Shandong Medical College,Ji'nan,Shandong,250002,China)

机构地区：[1]山东第一医科大学附属省立医院远程医学中心,山东济南250021 [2]山东第一医科大学附属省立医院病案管理科,山东济南250021 [3]山东第一医科大学附属济南市中心医院眼科,山东济南250013 [4]山东医学高等专科学校临床医学系,山东济南250002

出　　处：《现代生物医学进展》2024年第19期3744-3746,3703,共4页Progress in Modern Biomedicine

基　　金：国家重点研究发展计划项目(2018YFC2002000)。

摘　　要：目的:探讨血清蜂窝通信网络因子1(CCN1)、CCN2与糖尿病视网膜病变(DR)患者微血管损伤的关系。方法:选取2型糖尿病患者147例(观察组)和体检健康的75名志愿者(对照组),根据DR发生情况将2型糖尿病患者分为增生型DR(PDR)组、非PDR(NPDR)组、眼底正常组。检测并比较血清CCN1、CCN2水平以及微血管损伤指标。分析2型糖尿病患者发生DR的影响因素。结果:观察组血清CCN1、CCN2水平均高于对照组(P<0.05)。PDR组血清CCN1、CCN2水平和外周血CEC比例均高于NPDR组,EPC、CPC比例均低于NPDR组(P<0.05),NPDR组血清CCN1、CCN2水平和外周血循环内皮细胞(CEC)比例均高于眼底正常组,内皮祖细胞(EPC)、循环祖细胞(CPC)比例均低于眼底正常组(P<0.05)。2型糖尿病病程延长、糖化血红蛋白升高、血清CCN1、CCN2水平升高为2型糖尿病患者发生DR的独立危险因素(P<0.05)。结论:血清CCN1、CCN2水平升高与DR患者微血管损伤程度加重有关,是2型糖尿病患者发生DR的独立危险因素。Objective:To investigate the relationship between serum cellular communication network factor 1(CCN1),CCN2 and microvascular injury in patients with diabetic retinopathy(DR).Methods:147 patients with type 2 diabetes mellitus(observation group)and 75 volunteers(control group)were selected,patients with type 2 diabetes mellitus were divided into proliferative DR(PDR)group non-PDR(NPDR)group and normal fundus group according to the occurrence and development of DR.The levels of serum CCN1,CCN2 and microvascular injury indexes were detected and compared.the influencing factors of the occurrence of DR in patients with type 2 diabetes were analyzed.Results:The levels of serum CCN1 and CCN2 in observation group were higher than those in control group(P<0.05).The levels of serum CCN1 and CCN2 and the proportion of circulating endothelial cells(CEC)in peripheral blood in PDR group were higher than those in NPDR group,and the proportions of endothelial progenitor cells(EPC)and circulating progenitor cells(CPC)were lower than those in NPDR group(P<0.05),the levels of serum CCN1 and CCN2 and the proportion of CEC in peripheral blood in NPDR group were higher than those in normal fundus group,and the proportions of EPC and CPC were lower than those in normal fundus group(P<0.05).Prolonged duration of type 2 diabetes,elevated glycosylated hemoglobin,elevated serum CCN1 and CCN2 levels were independent risk factors for the occurrence of DR in patients with type 2 diabetes(P<0.05).Conclusion:The increase of serum CCN1 and CCN2 levels are relate to the aggravation of microvascular injury in DR patients,which are independent risk factors for the occurrence of DR in patients with type 2 diabetes.

关 键 词：糖尿病视网膜病变 蜂窝通信网络因子1 蜂窝通信网络因子2 微血管损伤 

分 类 号：R774[医药卫生—眼科] R587.2[医药卫生—临床医学]