肝移植治疗肝门部胆管癌的现状与进展  

Current status and progress of liver transplantation in the treatment of perihilar cholangiocarcinoma

作　　者：王灏 王志鑫[1,2] 侯立朝 樊海宁[1,2] 王海久 WANG Hao;WANG Zhi-xin;HOU Li-zhao;FAN Hai-ning;WANG Hai-jiu(Department of Hepatobiliary and Pancreatic Surgery,Affiliated Hospital of Qinghai University,Xining 810001,China;Qinghai Provincial Key Laboratory of Hydatid Disease Research,Xining 810001,China)

机构地区：[1]青海大学附属医院肝胆胰外科,青海西宁810001 [2]青海省包虫病研究重点实验室,青海西宁810001

出　　处：《实用医院临床杂志》2024年第6期35-38,共4页Practical Journal of Clinical Medicine

基　　金：青海大学附属医院肝胆外科(包虫病)国家临床重点专科建设项目(编号:青卫健办-125号);青海科技厅2022年科技计划项目(青海省包虫病研究重点实验室)。

摘　　要：肝门部胆管癌(PHCC)源于肝外胆管黏膜上皮细胞,常在左、右肝管汇合部及肝总管上段位置发生,是肝外胆管癌中最常见类型的恶性肿瘤。由于其发病机制复杂及解剖结构特殊,多数患者早期并无明显特殊临床表现,当出现黄疸等症状确诊时病情已发展为中晚期,因此PHCC的诊治是临床医生所面临的重大难题。对于目前PHCC治疗,外科手术切除仍是主要有效的方式,而对于中晚期不可切除患者来说,肝移植是使患者获得长期生存可能的有效办法,且不受肿瘤分期及肝功能的约束,可以达到最大可能地切除病灶的效果。但目前肝移植治疗仍面临缺少供体肝脏来源。术后并发症及肿瘤复发等诸多争议与挑战。本文对肝移植在PHCC的治疗现状及进展进行系统综述。Perihilar cholangiocarcinoma(PHCC)originates from extrahepatic bile duct epithelial cells.It usually occurs at the junction of left and right hepatic ducts and superior hepatic ducts.It is the most common malignant tumor in extrahepatic cholangiocarcinoma.Due to its complex pathogenesis and special anatomical structure,most patients have no obvious special clinical manifestation in the early stage.When symptoms such as jaundice are diagnosed,the disease has progressed to the middle and late stages.Therefore,the diagnosis and treatment of PHCC is a major problem faced by clinicians.For the current treatment of PHCC,surgical resection is still the main effective way.For middle and advanced patients whose tumor cannot be surgically removed,liver transplantation is an effective method.It makes patients have the possibility of long-term survival,and is not limited by tumor stage and liver function.It also can achieve the maximum possible lesion resection.However,the treatment of liver transplantation still faces many controversies and challenges,such as lack of donor liver sources,postoperative complications and tumor recurrence.This article systematically reviews the current status and progress of PHCC liver transplantation.

关 键 词：肝门部胆管癌 肝移植 根治性切除 

分 类 号：R735.8[医药卫生—肿瘤]