益生菌联合低聚半乳糖及肠内营养在重症颅脑损伤患者中的应用效果  

The application effect of probiotics combined with galacto-oligosaccharides and enteral nutrition in patients with severe craniocerebral injury

作　　者：张俊杰 王春晓 肖丽丽 明燕 王蕾 ZHANG Jun-jie;WANG Chun-xiao;XIAO Li-li;MING Yan;WANG Lei(Department of Emergency,The First Affiliated Hospital of PLA Air Force Medical University,Xi'an 710032,China)

机构地区：[1]中国人民解放军空军军医大学第一附属医院急诊科,陕西西安710032

出　　处：《实用医院临床杂志》2024年第6期83-87,共5页Practical Journal of Clinical Medicine

基　　金：国家重点临床军事项目(编号:AWS15J001);国家重点军事科研项目(编号:BWS21J002)。

摘　　要：目的探讨对重症颅脑损伤患者采用益生菌联合低聚半乳糖及肠内营养的应用效果。方法将2023年1~12月我院急诊科收治的重症颅脑损伤患者150例,按照随机数字表法分为两组各75例,对照组采用肠内营养方案,研究组在对照组基础上加用益生菌联合低聚半乳糖方案,两组均治疗3个月。比较治疗前后两组患者的营养状态、炎症因子、格拉斯哥昏迷量表(GCS)评分、美国国立卫生研究院卒中量表(NIHSS)评分、感染及胃肠道不良反应发生情况。结果治疗后两组患者营养状态、炎症因子、GCS评分、NIHSS评分均优于治疗前,且研究组各指标优于对照组(P<0.05),研究组感染及胃肠道不良反应发生情况明显低于对照组(P<0.05)。结论益生菌联合低聚半乳糖及肠内营养可有效改善重症颅脑损伤患者的营养状况和神经功能,减轻炎症反应,降低胃肠道不良反应和感染的发生。Objective To investigate the application effects of probiotics combined with galacto-oligosaccharides and enteral nutrition in patients with severe cranial brain injury.Methods From January to December 2023,150 patients with severe cranial brain injury admitted to the emergency department of our hospital were selected.The patients were divided into a control group and a study groups by using random number table method,75 in each group.The control group was treated with an enteral nutrition scheme.The study group added a probiotic combined with galacto-oligosaccharides scheme on the basis of the control group.Both groups were treated for 3 months.The nutritional status,inflammatory factors,Glasgow Coma Scale(GCS)scores,National Institutes of Health Stroke Scale(NIHSS)scores,incidence of infection,and gastrointestinal adverse reactions before and after treatment were compared between the two groups.Results After treatment,the nutritional status,inflammatory factors,GCS scores,and NIHSS scores of the patients in both groups were better than before treatment,and all indicators in the study group were better than those in the control group(P<0.05).The incidence of infection and gastrointestinal adverse reactions in the study group was significantly lower than that in the control group(P<0.05).Conclusions The combination of probiotics with galacto-oligosaccharides and enteral nutrition can effectively improve the nutritional status and neurological function of patients with severe cranial brain injury.It also can reduce the inflammatory reactions,and decrease the incidence of gastrointestinal adverse reactions and infections.

关 键 词：重症颅脑损伤 益生菌 低聚半乳糖 肠内营养 神经功能 

分 类 号：R459.3[医药卫生—治疗学]