非小细胞肺癌患者CPNE 1蛋白、Beclin-1蛋白变化及与临床分期、预后的关系  

Changes of CPNE 1 protein and Beclin-1 protein in NSCLC patients and their relationship with clinical staging and prognosis

作　　者：赵晨阳 房涛 吴海永 陈雯 徐志富 蔡宝松 ZHAO Chen-yang;FANG Tao;WU Hai-yong;CHEN Wen;XU Zhi-fu;CAI Bao-song(Zhangjiakou First Hospital,Zhangjiakou 075000,China)

机构地区：[1]河北省张家口市第一医院,河北张家口075000

出　　处：《实用医院临床杂志》2024年第6期108-112,共5页Practical Journal of Clinical Medicine

基　　金：河北省医学科学研究项目(编号:20201599);张家口市重点研发计划项目(编号:1921083D)。

摘　　要：目的探讨CPNE1蛋白和Beclin-1蛋白在非小细胞肺癌(NSCLC)患者中的表达变化及其与临床分期、预后的关系。方法我院收治的98例NSCLC患者,穿刺取NSCLC患者肺癌组织作为NSCLC组,取距肺癌组织≥5cm的癌旁组织作为对照组。比较不同组织CPNE1蛋白、Beclin-1蛋白变化,比较NSCLC组不同临床分期CPNE1蛋白、Beclin-1蛋白变化。分析NSCLC组PFS、OS与CPNE1蛋白、Beclin-1蛋白的关系;采用Cox比例风险模型分析NSCLC患者预后的影响因素。结果NSCLC组CPNE1蛋白高表达占比高于对照组,Beclin-1蛋白高表达占比低于对照组(P<0.05);Ⅲ~Ⅳ期CPNE1蛋白高表达占比高于Ⅰ~Ⅱ期,Beclin-1蛋白高表达占比低于Ⅰ~Ⅱ期(P<0.05)。随访结束,98例NSCLC患者中位PFS为9.26个月,中位OS为12.55个月。NSCLC组CPNE1蛋白低表达者PFS、OS趋势优于高表达者;Beclin-1蛋白高表达者PFS、OS趋势优于低表达者(P<0.05)。经Cox比例风险模型单因素分析,肿瘤临床分期、CPNE1蛋白高表达、Beclin-1蛋白低表达是影响NSCLC患者预后的单因素(P<0.05);多因素分析显示临床分期、CPNE1蛋白、Beclin-1蛋白是影响NSCLC患者OS的预后危险因素(P<0.05)。结论在NSCLC患者组织中CPNE 1蛋白、Beclin-1蛋白分别呈高、低表达,CPNE 1蛋白、Beclin-1蛋白在NSCLC中的表达变化与其临床分期、预后存在一定的关联,为NSCLC的诊断和治疗提供了新的依据和思路。Objective To investigate the changes in the expression of CPNE 1 protein and Beclin-1 protein in patients with non-small cell lung cancer(NSCLC)and their relationship with clinical staging and prognosis.Methods Ninety-eight NSCLC patients admitted to our hospital were selected.The lung cancer tissues of the patients were taken by puncture(NSCLC group).The paracancerous tissues≥5cm away from the lung cancer tissues were taken as control group.The changes of CPNE 1 protein and Beclin-1 protein in different tissues were compared.The changes of CPNE 1 protein and Beclin-l protein in different clinical stages in the NSCLC group were also compared.The relationship between progress-free survival(PFS),overall survival(OS)and CPNE 1 protein and Beclin-1 protein in the NSCLC group was analyzed.Cox proportional risk model was used to analyze the influencing factors of prognosis of the NSCLC patients.Results The percentage of high expression of CPNE 1 protein was higher and the percentage of high expression of Beclin-1 protein was lower in the NSCLC group than those in the control group(P<0.05).The percentage of high expression of CPNE 1 protein was higher and the percentage of high expression of Beclin-1 protein was lower in stage Ⅲ~Ⅳ than those in stage Ⅰ~Ⅱ(P<0.05).At the end of follow-up,the 98 NSCLC patients had a median PFS of 9.26 months and a median OS of 12.55 months.The trend of PFS and OS in the NSCLC group was better in those with low expression of CPNE 1 protein than in those with high expression,and the trend of PFS and OS in those with high expression of Beclin-1 protein was better than that in those with low expression(P<0.05).Univariate analysis of Cox proportional risk model showed that higher clinical stage of tumor,high expression of CPNE 1 protein,and low expression of Beclin-1 protein were single factors affecting the prognosis of NSCLC patients(P<0.05).Multivariate analysis showed that clinical stage,CPNE 1 protein,and Beclin-1 protein were prognostic risk factors affecting the OS of NSCLC pat

关 键 词：非小细胞肺癌 CPNE1蛋白 Beclin-1蛋白 临床分期 预后 

分 类 号：R734.2[医药卫生—肿瘤]