食管癌患者血管内皮因子、应答因子、缺氧诱导因子变化及临床意义  

Changes and clinical significance of vascular endothelial growth factor,serum response factor and hypoxia-inducible factor in patients with esophageal cancer

作　　者：陈建兴 庄云英[1] 陈玲红[1] 吴美玉 CHEN Jian-xing;ZHUANG Yun-ying;CHEN Ling-hong;WU Mei-yu(The 910th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China,Quanzhou 362000,China)

机构地区：[1]中国人民解放军联勤保障部队第910医院,福建泉州362000

出　　处：《实用医院临床杂志》2024年第6期113-116,共4页Practical Journal of Clinical Medicine

基　　金：福建省自然科学基金资助项目(编号:2022J01311)。

摘　　要：目的探讨食管癌患者血管内皮因子(VEGF-C)、血清应答因子(SRF)、缺氧诱导因子(HIF-1α)变化及临床意义。方法我院就诊94例食管癌患者为观察组,同期112例健康体检人群为对照组,对比两组基本资料以及血清VEGF-C、SRF、HIF-1α水平变化。食管癌患者均接受放疗治疗,对比放疗前、1疗程后其血清VEGF-C、SRF、HIF-1α水平变化,以放疗后疗效作为依据将食管癌患者分为有效组(n=62)与无效组(n=32),对比两组血清VEGF-C、SRF、HIF-1α水平,并绘制ROC曲线分析上述血清指标对患者治疗效果的预测价值。结果入组时观察组血清VEGF-C、HIF-1α水平、SRF阳性率显著高于对照组(P<0.05)。放疗4周后观察组血清VEGF-C、HIF-1α水平、SRF阳性率均明显下降(P<0.05)。有效组血清VEGF-C、HIF-1α水平、SRF阳性率显著低于无效亚组(P<0.05)。血清VEGF-C、HIF-1α对于食管癌患者治疗效果具有较高的预测价值(AUC>0.7)。结论食管癌患者血清VEGF-C、SRF、HIF-1α水平表现为高水平表达,而血清VEGF-C、HIF-1α对患者放疗效果具有一定预测价值。Objective To explore the changes and clinical significance of vascular endothelial growth factor C(VEGF-C),serum response factor(SRF)and hypoxia-inducible factor(HIF-lα)in patients with esophageal cancer.Methods Ninety-four patients with esophageal cancer treated in our hospital were enrolled as an observation group.At the same time,l12 healthy people with physical examination were included in a control group.The basic data and changes in levels of serum VEGF-C,SRF and HIF-1αwere compared between the two groups.All patients with esophageal cancer received radiotherapy.The changes of serum VEGF-C,SRF and HIF-1αlevels before and after 1 course of radiotherapy were compared.The esophageal cancer were classified into an effective subgroup(n=62)and ineffective subgroup(n=32)according to efficacy of radiotherapy.The levels of serum VEGF-C,SRF and HIFlαwere compared between the two subgroups.ROC curve was drawn to analyze the predictive value of the above serum indicators for the therapeutic effect.Results The levels of serum VEGF-C and HIF-lαand positive rate of SRF in the observation group after enrollment were significantly higher than those in the control group(P<0.05).After 4 weeks of radiotherapy,serum VEGF-C,HIF-1αand positive rate of SRF in the observation group were significantly decreased(P<0.05).The levels of serum VEGF-C and HIF-1αand positive rate of SRF were significantly lower in the effective subgroup than those in the ineffective subgroup(P<0.05).Serum VEGF-C and HIF-1αhad high predictive value for therapeutic effect of patients with esophageal cancer(AUC>0.7).Conclusions The levels of serum VEGF-C,SRF and HIF-1αare highly expressed in patients with esophageal cancer.Serum VEGF-C and HIF-1αhave certain predictive value for the effect of radiotherapy.

关 键 词：食管癌 血管内皮因子 血清应答因子 缺氧诱导因子 

分 类 号：R735.1[医药卫生—肿瘤]