肿瘤转移相关基因1、血管内皮生长因子C在肺癌术前评估中的价值分析  

Analysis of the value of tumor metastasis-related gene 1 and vascular endothelial growth factor C in preoperative assessment of lung cancer

作　　者：许峰[1] 陈一彪 居冠军[1] XU Feng;CHEN Yi-biao;JU Guan-Jun(Nantong Tumor Hospital/Tumor Hospital Affiliated to Nantong University,Nantong 226361,China)

机构地区：[1]江苏省南通市肿瘤医院/南通大学附属肿瘤医院,江苏南通226361

出　　处：《实用医院临床杂志》2024年第6期116-119,共4页Practical Journal of Clinical Medicine

基　　金：江苏省卫生健康委科研基金资助项目(编号:K2019021)。

摘　　要：目的探讨肿瘤转移相关基因1(MTA1)、血管内皮生长因子C(VEGF-C)检测在肺癌患者术前分期及淋巴结转移中的评估价值。方法我院收治的203例接受手术治疗的肺癌患者,比较肿瘤组织及癌周正常组织MTA1、VEGF-C表达阳性率,采用Spearman相关性分析MTA1与VEGF-C表达的关系,不同临床资料患者MTA1、VEGF-C阳性表达率,采用Logistics回归分析肺癌患者淋巴结转移影响因素,比较不同淋巴结转移情况肺癌患者肿瘤组织MTA1、VEGF-C表达量,采用ROC曲线获取MTA1、VEGF-C诊断肺癌淋巴结转移表达量截断值并判断诊断价值。结果肿瘤组织MTA1、VEGF-C表达阳性率高于癌周正常组织(P<0.05),MTA1与VEGF-C表达阳性正相关(P<0.05),肿瘤中低分化的MTA1、VEGF-C阳性表达占比均高于肿瘤高分化,术前ⅢA期MTA1、VEGF-C阳性表达占比均高于术前Ⅰ期,淋巴结转移的MTA1、VEGF-C阳性表达占比均淋巴结未转移(P<0.05)。MTA1、VEGF-C表达阳性为肺癌患者淋巴结转移的独立危险因素(P<0.05),淋巴结转移患者肿瘤组织MTA1、VEGF-C表达量高于淋巴结未转移患者(P<0.05)。MTA1、VEGF-C对肺癌淋巴结转移AUC为0.837、0.819,均具有良好诊断效能(P<0.05)。结论MTA1与VEGF-C互相影响,在肺癌组织发生发展过程中发挥重要作用,MTA1、VEGF-C表达阳性提示患者存在较高淋巴结转移风险,通过检测MTA1、VEGF-C表达量有助于判断肺癌患者淋巴结转移。Objective To explore the appraisal value of tumor metastasis-associated gene 1(MTAI)and vascular endothelial growth factor C(VEGF-C)for preoperative staging and lymph node metastasis in patients with lung cancer.Methods Two hundred and three patients with lung cancer received surgical treatment in our hospital were selected.The positive expression rates of MTA1 and VEGF-C in tumor tissues and adjacent normal tissues were compared.Spearman correlation analysis was used to analyze the relationship between MTA1 and VEGF-C expressions.The positive expression rates of MTA1 and VEGF-C were compared among patients with different clinical data.Logistics regression analysis was applied to analyze the influencing factors of lymph node metastasis in lung cancer patients.The expressions of MTA1 and VEGF-C in tumor tissues of lung cancer patients with dfferent lymph node metastasis were compared.ROC curve analysis was used to obtain the cut-off values of MTAl and VEGF-C in the diagnosis of lymph node metastasis of lung cancer and to judge the diagnostic value.Results The positive expression rates of MTA1 and VEGF-C in tumor tissues were higher than those in adjacent normal tissues(P<0.05).MTA1 was positively correlated with positive expression of VEGF-C(P<0.05).The proportions of positive expressions of MTA1 and VEGF-C in poorly differentiated tumors were higher than those in highly differentiated tumors,and the proportions in preoperative stage IIA were higher than those in preoperative stage I,and the proportions in lymph node metastasis were higher than those without lymph node metastasis(P<0.05).The positive expressions of MTA1 and VEGF-C were independent risk factors for lymph node metastasis in patients with lung cancer(P<0.05).The expression levels of MTA1 and VEGF-C in tumor tissues of patients with lymph node metastasis were higher than those of patients without lymph node metastasis(P<0.05).The AUCs of MTA1 and VEGF-C for lymph node metastasis of lung cancer were 0.837 and 0.819,and both had good diagnostic efficien

关 键 词：肿瘤转移相关基因1 血管内皮生长因子C 术前分期 淋巴结转移 

分 类 号：R734.2[医药卫生—肿瘤]