食管癌患者miR-34a-5P、miR-204变化及与预后的关系分析  

Analysis of changes in miR-34a-5P and miR-204 and their relationship with prognosis in patients with esophageal cancer

作　　者：张勇[1] 赵园园[1] 张萍[2] 任玉峰[1] ZHANG Yong;ZHAO Yuan-yuan;ZHANG Ping;REN Yu-feng(Shanxi Provincial Cancer Hospital/Shanxi Hospital of Cancer Hospital Affiliated to Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University,Taiyuan 030013,China;School of Public Health,Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西省肿瘤医院/中国医学科学院肿瘤医院山西医院/山西医科大学附属肿瘤医院,山西太原030013 [2]山西医科大学公共卫生学院,山西太原030001

出　　处：《实用医院临床杂志》2024年第6期129-131,共3页Practical Journal of Clinical Medicine

基　　金：山西省基础研究计划项目(编号:202203021222386)。

摘　　要：目的分析食管癌患者miR-34a-5P、miR-204变化及与预后的关系。方法2019年5月至2022年12月山西省肿瘤医院收治的183例食管癌患者,根据食管癌分期分为早期组(n=76)、中期组(n=58)和晚期组(n=49),比较三组miR-34a-5P、miR-204水平。再根据治疗1年后患者预后情况分为未进展组(n=33)进展组(n=98)和死亡组(n=52),比较三组miR-34a-5P、miR-204水平。分析食管癌患者miR-34a-5P、miR-204水平与食管癌分期及预后的相关性。结果晚期组miR-34a-5P、miR-204水平低于中期组和早期组,中期组低于早期组(P<0.05);死亡组miR-34a-5P、miR-204水平低于进展组和未进展组,进展组低于未进展组(P<0.05);miR-34a-5P、miR-204水平与食管癌病情呈负相关、与食管癌患者预后呈正相关(P<0.05)。结论食管癌患者miR-34a-5P、miR-204水平随病情的加重逐渐降低,miR-34a-5P、miR-204低表达预示着患者预后情况越差。Objective To analyze the changes of miR-34a-5P and miR-204 in patients with esophageal cancer and their relationship with prognosis.Methods One hundred and eighty-three patients with esophageal cancer in shanxi provincial cancer hospital from May 2019 to December 2022 were selected.According to the esophageal cancer staging,the patients were divided into an early group(n=76),a middle group(n=58)and a late group(n=49).The levels of miR-34a-5P and miR-204 were compared among the three groups.By means of the prognosis status of patients after 1 year of treatment,they were classified into a non-progression group(n=33),a progression group(n=98)and a death group(n=52).The levels of miR-34a-5P and miR-204 were compared.The correlation between the levels of miR-34a-5P and miR-204 in patients with esophageal cancer and the staging and prognosis of esophageal cancer was analyzed.Results The levels of miR-34a-5P and miR-204 in the late group were lower than those in the middle group and the early group(P<0.05),and the above levels in middle group were lower than those in the early group(P<0.05).The levels of miR-34a-5P and miR-204 were lower in the death group than those in the progression group and the non-progression group(P<0.05),and the progression group were lower than the non-progression group(P<0.05).The levels of miR-34a-5P and miR-204 were negatively correlated with disease condition of esophageal cancer(P<0.05),and were positively correlated with prognosis of patients with esophageal cancer(P<0.05).Conclusions The expression levels of miR-34a-5P and miR-204 in patients with esophageal cancer are gradually decreased with the aggravation of the disease.The low expressions of miR-34a-5P and miR-204 indicate the worse prognosis of the patients.

关 键 词：食管癌 miR-34a-5P miR-204 预后 

分 类 号：R735.1[医药卫生—肿瘤]