小牛血去蛋白提取物眼用凝胶联合右旋糖酐羟丙甲纤维素滴眼液治疗干眼症的效果观察  

Observation on the Effect of Deproteinized Calf Blood Extract Eye Gel Combined with Dextran Hydroxypropyl Methylcellu-lose Eye Drops in the Treatment of Xerophthalmia

作　　者：夏花如 李晓艳 XIA Huaru;LI Xiaoyan(Department of Ophthalmology,Puyang Huimin Hospital,Puyang 457000,China)

机构地区：[1]濮阳惠民医院眼科,河南濮阳457000

出　　处：《临床医学工程》2024年第11期1399-1400,共2页Clinical Medicine & Engineering

摘　　要：目的观察小牛血去蛋白提取物眼用凝胶联合右旋糖酐羟丙甲纤维素滴眼液治疗干眼症的临床效果。方法将80例干眼症患者随机分为参照组(40例)和联合组(40例)。参照组采用右旋糖酐羟丙甲纤维素滴眼液治疗,联合组采用小牛血去蛋白提取物眼用凝胶联合右旋糖酐羟丙甲纤维素滴眼液治疗,均连续治疗2周。比较两组的临床疗效、泪膜稳定性指标及不良反应发生情况。结果联合组治疗总有效率为95.00%,高于参照组的80.00%(P<0.05)。治疗2周后,联合组BUT长于对照组,SIt值高于参照组,FL评分低于参照组(P<0.05)。治疗期间两组不良反应发生率比较无统计学差异(P>0.05)。结论小牛血去蛋白提取物眼用凝胶联合右旋糖酐羟丙甲纤维素滴眼液治疗干眼症可明显提升临床疗效,增强患者的泪膜稳定性,且安全可靠。Objective To observe the clinical effect of deproteinized calf blood extract eye gel combined with dextran hydroxypropyl methylcellulose eye drops in the treatment of xerophthalmia.Methods 80 patients with xerophthalmia were randomly divided into reference group(40 cases)and combined group(40 cases).The reference group was treated with dextran hydroxypropyl methylcellulose eye drops,and the combined group was treated with deproteinized calf blood extract eye gel combined with dextran hydroxypropyl methylcellulose eye drops.Both groups were treated continuously for 2 weeks.The clinical efficacy,tear film stability indicators and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the combined group was 95.00%,higher than 80.00%in the reference group(P<0.05).After 2 weeks of treatment,the BUT of the combined group was longer than that of the control group,the SIt value was higher than that of the reference group,and the FL score was lower than that of the reference group(P<0.05).During treatment,no statistical difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Deproteinized calf blood extract eye gel combined with dextran hydroxypropyl methylcellulose eye drops in the treatment of xerophthalmia can significantly improve the clinical efficacy,enhance the tear film stability in patients,and is safe and reliable.

关 键 词：干眼症 小牛血去蛋白提取物眼用凝胶 右旋糖酐羟丙甲纤维素滴眼液 泪液蛋白 临床疗效 

分 类 号：R777.34[医药卫生—眼科]