Thirty years of Ca^(2+)spark research:digital principle of cell signaling unveiled  

作　　者：Fujian Lu Pengcheng Yang Donghui Zhang Xianhua Wang Heping Cheng 

机构地区：[1]Department of Cardiology,Zhongshan Hospital,Institutes of Biomedical Sciences,Fudan University,Shanghai Institute of Cardiovascular Diseases,Shanghai 200032,China [2]State Key Laboratory of Biocatalysis and Enzyme Engineering,School of Life Science,Hubei University,Wuhan 430062,China [3]National Biomedical Imaging Center,State Key Laboratory of Membrane Biology,Peking-Tsinghua Center for Life Sciences,College of Future Technology,Peking University,Beijing 100871,China

出　　处：《Biophysics Reports》2024年第5期259-265,共7页生物物理学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(32293211,61972009,92157105,81827809)(to HC)and JIH1340085Y(to FL)。

摘　　要：Calcium ions(Ca^(2+))are an archetypical and most versatile second messenger in virtually all cell types.Inspired by the discovery of Ca^(2+)sparks in the 1990s,vibrant research over the last three decades has unveiled a constellation of Ca^(2+)microdomains as elementary events of Ca^(2+)signaling and,more importantly,a digital-analog dualism as the system design principle of Ca^(2+)signaling.In this brief review,we present a sketchy summary on advances in the field of sparkology,and discuss how the digital subsystem can fulfill physiological roles otherwise impossible for any analog system.In addition,we attempt to address how the digital-analog dualism endows the simple cation messenger with signaling speediness,specificity,efficiency,stability,and unparalleled versatility.

关 键 词：CA^(2+) SIGNALING ^(2+) MICRODOMAIN DIGITAL system design 

分 类 号：Q257[生物学—细胞生物学]