多发性骨髓瘤患者合并静脉血栓栓塞风险评估模型的研究现状  

Research status of risk assessment models for venous thromboembolism in patients with multiple myeloma

作　　者：刘月霄 王立茹[1] 路瑾[2] Liu Yuexiao;Wang Liru;Lu Jin(Fuxing Hospital Affiliated to Capital Medical University,Beijing 100038,China;Peking University Institute of Hematology,Peking University People′s Hospital,Beijing 100044,China)

机构地区：[1]首都医科大学附属复兴医院血液科,北京100038 [2]北京大学人民医院北京大学血液研究所,北京100044

出　　处：《国际输血及血液学杂志》2024年第3期193-200,共8页International Journal of Blood Transfusion and Hematology

基　　金：首都卫生发展科研专项项目(2020-2-4082)。

摘　　要：多发性骨髓瘤(MM)是一种浆细胞克隆性疾病,静脉血栓栓塞(VTE)是其主要并发症之一。高龄、白色人种、高免疫球蛋白血症所致的高凝状态,以及应用免疫调节剂(IMiD)、红细胞生成素(EPO)等因素,均可增加MM患者合并VTE的风险,严重影响患者的预后及长期生存。有效的风险评估模型(RAM)可准确地对MM患者进行VTE风险分层,对改善患者预后具有深远临床意义。笔者拟就MM患者合并VTE的危险因素及国内外现行RAM的研究现状进行阐述,旨在提高临床医师对该病的识别。Multiple myeloma(MM)is a clonal disease of plasma cells,and venous thromboembolism(VTE)is one of its main complications.Factors such as age,caucasians,hypercoagulability caused by hyperimmunoglobulinemia,and the use of immunomodulatory drug(IMiD)and erythropoietin(EPO)can increase the risk of VTE in MM patients,and seriously affect the prognosis and long-term survival of patients.An effective risk assessment model(RAM)can accurately stratify the risk of VTE in patients with MM,which has far-reaching clinical significance for improving the prognosis of patients.This article elaborates on the risk factors of VTE in MM patients and research status of RAM at home and abroad,aiming to improve the recognition of this disease by clinicians.

关 键 词：多发性骨髓瘤 静脉血栓栓塞 风险评估 血栓形成倾向 危险因素 

分 类 号：R733.3[医药卫生—肿瘤] R543.6[医药卫生—临床医学]