盐酸哌罗匹隆联合小剂量氨磺必利对难治性精神分裂症糖脂代谢水平的影响  

Effect of perospirone hydrochloride combined with low dose amisulpride on glucose and lipid metabolism in refractory schizophrenia

作　　者：陈坤玲 CHEN Kunling(Department of Pharmacy,Zhumadian Second People's Hospital,Zhumadian,Henan 463000,China)

机构地区：[1]驻马店市第二人民医院药学部,河南驻马店463000

出　　处：《中国医学工程》2024年第11期78-82,共5页China Medical Engineering

摘　　要：目的旨在观察盐酸哌罗匹隆联合小剂量氨磺必利对难治性精神分裂症的影响效果,并探讨其应用价值。方法选取2022年2月至2023年2月在驻马店市第二人民医院接受治疗的120例难治性精神分裂症,根据随机数字表法将其分为对照组(n=60)给予盐酸哌罗匹隆治疗,观察组(n=60)给予盐酸哌罗匹隆联合小剂量氨磺必利治疗,比较两组患者精神症状、空腹血糖(FBG)、血清泌乳素(PRL)、血脂水平和社会功能改善情况。结果干预3个月后,阳性与阴性症状量表(PANSS)中3个维度的评分在两组患者中均降低,观察组均低于对照组,差异有统计学意义(P<0.05);干预3个月后,FBG、PRL、总胆固醇(TC)、甘油三酯(TG)水平在两组患者中均升高,观察组FBG、TC、TG水平均低于对照组,PRL水平高于对照组,差异有统计学意义(P<0.05);干预3个月后,个人和社会功能量表(PSP)中4个维度的评分在两组患者中均升高,观察组均高于对照组(P<0.05)。结论盐酸哌罗匹隆联合小剂量氨磺必利有利于难治性精神分裂症患者临床症状的改善,可维持糖脂代谢稳定,还有利于患者社会功能情况的改善。【Objective】To observe the effect of perospirone hydrochloride combined with low dose amisulpride on refractory schizophrenia and explore its application value.【Methods】A total of 120 patients with refractory schizophrenia who received treatment in Zhumadian Second People's Hospital from February 2022 to February 2023 were selected and divided into control group(n=60)and observation group(n=60),respectively.The improvement of psychiatric symptoms,fasting blood glucose(FBG),serum prolactin(PRL),blood lipids and social function were compared between the two groups.【Results】After 3 months of intervention,the scores of the three dimensions of the Positive and Negative Syndrome Scale(PANSS)decreased in both groups,the observation group was lower than the control group,and the difference was statistically significant(P<0.05).After 3 months of intervention,the levels of FBG,PRL,total cholesterol(TC)and triglyceride(TG)increased in both groups.The levels of FBG,TC and TG in the observation group were lower than those in the control group,and the level of PRL was higher than that in the control group(P<0.05).After 3 months of intervention,the scores of four dimensions in the Personal and Social Performance(PSP)scale increased in both groups,and the observation group was higher than the control group(P<0.05).【Conclusion】Perospirone hydrochloride combined with low dose amisulpride is beneficial to the improvement of clinical symptoms in patients with refractory schizophrenia,which can maintain the stability of glucose and lipid metabolism,and is also conducive to the improvement of patients'social function.

关 键 词：哌罗匹隆 小剂量氨磺必利 难治性精神分裂症 糖脂代谢 

分 类 号：R749.05[医药卫生—神经病学与精神病学]