Revealing the crucial roles of suppressive immune microenvironment in cardiac myxoma progression  

作　　者：Zedong Jiang Qianlong Kang Hong Qian Zhijie Xu Huan Tong Jiaqing Yang Li Li Renwei Li Guangqi Li Fei Chen Nan Lin Yunuo Zhao Huashan Shi Juan Huang Xuelei Ma 

机构地区：[1]Department of Biotherapy,State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu,Sichuan,China [2]Frontiers Science Center for Disease-related Molecular Network,West China Hospital,Sichuan University,Chengdu,Sichuan,China [3]Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education,College of Life Sciences,Sichuan University,Chengdu,Sichuan,China [4]Department of Cardiovascular Surgery,West China Hospital,Sichuan University,Chengdu,Sichuan,China [5]Department of Pathology,Xiangya Hospital,Central South University,Changsha,Hunan,China [6]Institute of Clinical Pathology,West China Hospital,Sichuan University,Chengdu,Sichuan,China [7]Department of Hematology,Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第9期4014-4029,共16页信号转导与靶向治疗（英文）

基　　金：supported by the Natural Science Foundation of Sichuan Province(2022NSFSC0774);the Sichuan Science and Technology Regional Collaboration Project(2023YFQ0012).

摘　　要：Cardiac myxoma is a commonly encountered tumor within the heart that has the potential to be life-threatening.However,the cellular composition of this condition is still not well understood.To fill this gap,we analyzed 75,641 cells from cardiac myxoma tissues based on single-cell sequencing.We defined a population of myxoma cells,which exhibited a resemblance to fibroblasts,yet they were distinguished by an increased expression of phosphodiesterases and genes associated with cell proliferation,differentiation,and adhesion.The clinical relevance of the cell populations indicated a higher proportion of myxoma cells and M2-like macrophage infiltration,along with their enhanced spatial interaction,were found to significantly contribute to the occurrence of embolism.The immune cells surrounding the myxoma exhibit inhibitory characteristics,with impaired function of T cells characterized by the expression of GZMK and TOX,along with a substantial infiltration of tumor-promoting macrophages expressed growth factors such as PDGFC.Furthermore,in vitro co-culture experiments showed that macrophages promoted the growth of myxoma cells significantly.In summary,this study presents a comprehensive single-cell atlas of cardiac myxoma,highlighting the heterogeneity of myxoma cells and their collaborative impact on immune cells.These findings shed light on the complex pathobiology of cardiac myxoma and present potential targets for intervention.

关 键 词：MYXOMA CARDIAC IMPAIRED 

分 类 号：R730.5[医药卫生—肿瘤]