Understanding genetics, sex and signaling: Implications of sex-dependent APOE4-neutrophil-microglia interactions for Alzheimer’s and tauopathies  

作　　者：Natja Haag Juliane Bremer Hans Zempel 

机构地区：[1]Institute for Human Genetics and Genomic Medicine,University Hospital RWTH Aachen,Aachen,Germany [2]Institute of Neuropathology,University Hospital RWTH Aachen,Aachen,Germany [3]Institute of Human Genetics,Faculty of Medicine and University Hospital Cologne,University of Cologne,Cologne,Germany [4]Center for Molecular Medicine Cologne(CMMC),University of Cologne,Cologne,Germany [5]Department of Nuclear Medicine,Faculty of Medicine and University Hospital Cologne,University of Cologne,Cologne,Germany

出　　处：《Signal Transduction and Targeted Therapy》2024年第10期4167-4169,共3页信号转导与靶向治疗（英文）

摘　　要：A recent study published in Nature Medicine uncovers a novel sex-dependent mechanism involving the apolipoprotein E ε4 (APOE4) and in particular neutrophils and their signaling to microglia, which then would mediate cognitive decline in late-onset Alzheimer’s disease (AD).1 We here put the main findings into perspective with current knowledge about APOE4 genotype and neutrophils in the pathogenesis of AD and related tauopathies, and discuss future research directions and therapeutic implications.

关 键 词：ALZHEIMER tau Medicine 

分 类 号：R749.16[医药卫生—神经病学与精神病学]