Differences and potential mechanisms of theta oscillation and temporoparietal and temporal-central networks in temporal lobe epilepsy patients with unilateral hippocampal sclerosis  

作　　者：Chenxi Qiu Chenxi Zhong Ying Liu Liju Wang Yingying Tang Zhiyi Liu Sijia Guo Yingqi Jiang Enzhi Li Jing Lu Bo Yan Xiaoting Hao Dong Zhou 

机构地区：[1]MOE Key Lab for Neuroinformation,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu,Sichuan,611731,China [2]Department of Neurology,West China Hospital,Sichuan University,Chengdu,Sichuan,610041,China [3]School of Nursing,Sichuan University,Sichuan,610041,China [4]Department of Neurology,Chengdu Shangjin Nanfu Hospital,Chengdu,Sichuan Province,611730,China [5]School of Public Health,Sichuan University,Chengdu,610044,China

出　　处：《Acta Epileptologica》2024年第3期204-214,共11页癫痫学报（英文）

基　　金：National Key R&D Program of China(2022YFC2503801);Cadre Health Care Project of the Sichuan Provincial Department of Health(2023–110);National College Student Innovation and Entrepreneurship Training Program(C2024131786).

摘　　要：Background There is a lack of further exploration of the epileptogenic network of specific types of epilepsy,such as unilateral hippocampal sclerosis(HS),and there is an urgent need to find exact evidence to confirm the consistency of its brain network changes.Methods We enrolled 22 mesial temporal lobe epilepsy with hippocampal sclerosis(mTLE-HS)patients to compare the differences in brain activity between 22 healthy controls(HCs)and them.Resting-state electroencephalography(EEG)was also measured.Then,we calculated the power spectral density and phase locking values in and between these electrodes.Results The results showed the increased theta power was related to the high severity of epilepsy in the temporal,parietal,and central regions in mTLE-HS patients,and there were positive correlations between theta power in the contralateral temporal region and seizure frequency.Theta power in the ipsilateral parietal lobe is positively correlated with the number of anti-seizure medications(ASMs),but not with the usage of third-generation ASMs.Meanwhile,the temporal lobe of mTLE-HS patients had more connectivity with parietal lobe and central region.

关 键 词：Mesial temporal lobe epilepsy Hippocampal sclerosis Electroencephalography Anti-seizure medications Theta oscillation 

分 类 号：R742.1[医药卫生—神经病学与精神病学]