Reversible leukoencephalopathy with seizures:a case of severe high-altitude cerebral edema  

作　　者：Ting Chen Xintong Wu Xiaoyan Liu Fengming Luo 

机构地区：[1]Department of High Altitude Medicine,Center for High Altitude Medicine,West China Hospital,Sichuan University,37 Guo Xue Xiang,Chengdu,Sichuan,610041,China [2]Department of Neurology,West China Hospital,Sichuan University,37 Guo Xue Xiang,Chengdu,Sichuan,610041,China [3]Department of Neurology,Lhasa People’s Hospital,1 Beijing Middle Road,Lhasa,Xizang,850000,China

出　　处：《Acta Epileptologica》2024年第3期238-243,共6页癫痫学报（英文）

基　　金：Tibet Science and Technology Program(No.XZ202201ZY0002G);Sichuan Science and Technology Program(No.2021YFQ0030).

摘　　要：Background Acute high-altitude illness(AHAI)refers to a series of syndromes including acute mountain sickness(AMS),high-altitude pulmonary edema(HAPE)and high-altitude cerebral edema(HACE).Among these,HACE is a severe and potentially life-threatening condition that can occur when individuals ascend to high altitudes.It is often characterized by ataxia,confusion,and altered mental status.Without appropriate treatment,HACE can rapidly progress to coma,but seizures are infrequent in occurrence.Case presentation Here,we report a severe HACE patient with coma and status epilepticus.The patient is a 23-year-old male who was visiting Lhasa for the first time.He initially experienced headaches and dizziness on the first day,and then he was found in coma with limb convulsions on the next day.Immediate medical attention was sought,and brain CT and MRI scans showed reversible white matter lesions,especially in the corpus callosum and subcortical white matter.Although the lesions disappeared on T1 and T2 sequences,microbleeds were observed on the SWI sequence.After treatment with tracheal intubation,glucocorticoids and hyperbaric oxygen,the cerebral edema has resolved and the clinical symptoms improved,the patient has no seizures anymore.Conclusions HACE typically follows AMS and poses a significant risk to life.Clinical manifestations mainly include ataxia,alterations of behavior,and impaired consciousness,with severe cases progressing to coma.Seizures,though rarely observed,may occur.Imaging shows reversible white matter lesions,with microbleeds being a significant and persistent imaging marker over time.Administration of glucocorticoids plays a crucial role in treatment.Despite experiencing seizures,this patient did not experienced any further episodes once his condition improved.

关 键 词：High-altitude cerebral edema Reversible leukoencephalopathy MICROBLEEDS Seizures Case report 

分 类 号：R742.1[医药卫生—神经病学与精神病学]