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作 者:王敏[1] 周玲 Wang Min;Zhou Ling(Department of Obstetrics and Gynecology,the Ninth Medical Center of PLA General Hospital,Beijing 100101,China)
机构地区:[1]中国人民解放军总医院第九医学中心妇产科,北京100101
出 处:《中华妇幼临床医学杂志(电子版)》2024年第4期374-381,共8页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
基 金:中国人民解放军总医院第九医学中心博士课题(21ZX15);吴阶平医学基金会临床科研专项资助基金(320.6750.18231)。
摘 要:近年育龄女性复发性流产(RSA)发病率呈逐年增高趋势,已成为生殖医学领域的严重问题。育龄女性RSA病因十分复杂,随着医学遗传学与生殖医学的发展,人们对RSA的遗传因素病因学研究已经较为深入。笔者拟就RSA的遗传因素,包括夫妇染色体异常、胚胎染色体异常及基因变异等的最新研究现状进行阐述,并探讨RSA遗传学检测的未来发展方向及可能涉及的医学伦理学问题,旨在为RSA的遗传因素病因学临床诊疗提供参考。In recent years,the incidence of recurrent spontaneous abortion(RSA)has shown an increasing trend,and has become an important issue in the field of reproductive health.The etiology of RSA in women of childbearing age is very complex,and with the development of medical genetics and reproductive genetics,people have gained more in-depth understanding of etiology of genetics factors associated with RSA.This review elaborates on progress of research on genetics factors of RSA,including chromosome abnormalities in couples,chromosomal abnormalities in embryos and genetic variants,and discusses the future direction of genetic testing for RSA and ethical issues that may be involved,with the aim of providing references for clinical diagnosis and treatment of genetic factors underlying etiology of RSA.
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