神经梅毒患者血清Cys-C、IL-12表达水平与伴发认知功能损害的相关性  

The expression levels of serum Cys-C and IL-12 in patients with neurosyphilis and their correlation with concomitant cognitive impairment

作　　者：徐继红[1] 张瑜 祖木热提·柯尤木 薄晓莉[2] 宋芳[3] XU Jihong;ZHANG Yu;ZUMURETI Keyoumu;BO Xiaoli;SONG Fang(Department of Public Health,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830000,China;Department of Gynecology,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830000,China;Department of STD and AIDS Prevention and Control,Urumqi Center for Disease Control and Prevention,Urumqi,Xinjiang 830000,China)

机构地区：[1]新疆医科大学第二附属医院公共卫生科,新疆乌鲁木齐830000 [2]新疆医科大学第二附属医院妇科,新疆乌鲁木齐830000 [3]乌鲁木齐市疾病预防控制中心性病艾滋病防制科,新疆乌鲁木齐830000

出　　处：《热带医学杂志》2024年第10期1416-1419,共4页Journal of Tropical Medicine

基　　金：新疆神经系统疾病研究重点实验室开放课题(XJDX1711-2240)。

摘　　要：目的探讨神经梅毒患者血清胱抑素C(Cys-C)、白介素-12(IL-12)表达与伴发认知功能损害的相关性,为临床降低神经梅毒伴发认知功能损害风险提供参考依据。方法选取2019年1月-2021年12月新疆医科大学第二附属医院收治的110例神经梅毒患者为神经梅毒组,同期选取45例梅毒患者为梅毒组。110例神经梅毒患者中,根据是否存在认知功能障碍分为认知功能障碍组(n=45)和无认知功能障碍组(n=65)。比较各组神经梅毒患者血清Cys-C、IL-12水平,采用Pearson分析神经梅毒患者血清Cys-C、IL-12水平与简易智力状态检查(MMSE)评分的相关性。结果神经梅毒组血清Cys-C水平高于梅毒组,血清IL-12水平低于梅毒组,差异均有统计学意义(t=4.747、17.971,P均<0.001)。认知功能障碍组血清Cys-C水平高于无认知功能障碍组,血清IL-12水平低于无认知功能障碍组,差异均有统计学意义(t=5.620、3.432,P均<0.001)。Pearson双变量相关分析结果显示,神经梅毒患者血清Cys-C与MMSE评分成负相关(r=-0.709,P<0.001),血清IL-12与MMSE评分成正相关(r=0.726,P<0.001)。结论神经梅毒患者血清Cys-C、IL-12均异常表达,且与认知功能障碍程度有关,检测血清Cys-C、IL-12水平有助于临床评估神经梅毒患者认知功能损害情况。Objective To investigate the expression levels of cystatin C(Cys-C)and interleukin-12(IL-12)in patients with neurosyphilis and their correlation with associated cognitive impairment.Methods A total of 110 patients with neurosyphilis admitted to the Second Affiliated Hospital of Xinjiang Medical University from January 2019 to December 2021 were selected as the neurosyphilis group,and 45 patients with syphilis were selected as the syphilis group during the same period.Among the 110 neurosyphilis patients,they were classified into cognitive dysfunction group(n=45)and without cognitive dysfunction group(n=65).The expressions levels of serum Cys-C and IL-12 were compared among the groups.The correlation between the expression levels of Cys-C and IL-12 in serum and mini-mental state examinatlon(MMSE)score in patients with neurosyphilis was analyzed by Pearson.Results The serum Cys-C level in neurosyphilis group was higher than that in syphilis group,and the serum IL-12 level was lower than that in syphilis group(t=4.747,17.971;all P<0.001).The serum Cys-C level of cognitive dysfunction group was higher than that without cognitive dysfunction group,and the serum IL-12 level was lower than that without cognitive dysfunction group(t=5.620,3.432;all P<0.001).Pearson bivariate correlation analysis showed that serum Cys-C level was negatively correlated with MMSE score in neurosyphilis patients(r=-0.709,P<0.001),and serum IL-12 level was positively correlated with MMSE score(r=0.726,P<0.001).Conclusions The abnormal expression of Cys-C and IL-12 in the serum of neurosyphilis patients was related to the degree of cognitive impairment.Detection of serum Cys-C and IL-12 levels could help clinical evaluation of cognitive impairment in neurosyphilis patients.

关 键 词：神经梅毒 胱抑素C 白介素-12 认知功能损害 

分 类 号：R741.05[医药卫生—神经病学与精神病学]