1例额颞叶痴呆并帕金森综合征患者的多模态正电子发射体层摄影-电子计算机体层扫描表现  

Multimodal positron-emission tomography-computed tomography manifestations in a case with frontotemporal dementia with parkinsonism

作　　者：邵靖雨 付畅 徐俊玲 陈帅 杨红旗 张杰文 Shao Jingyu;Fu Chang;Xu Junling;Chen Shuai;Yang Hongqi;Zhang Jiewen(Department of Neurology,People′s Hospital of Zhengzhou University,Henan Provincial People′s Hospital,Zhengzhou 450003,China)

机构地区：[1]郑州大学人民医院、河南省人民医院神经内科,郑州450003

出　　处：《中华神经科杂志》2024年第11期1254-1258,共5页Chinese Journal of Neurology

摘　　要：额颞叶痴呆(FTD)是一组以进行性精神行为异常、执行功能障碍、语言功能损害为主要特征的痴呆疾病。少数FTD患者在疾病的某个时期也可出现运动异常。文中报道1例FTD伴帕金森综合征的患者的临床及多模态正电子发射体层摄影(PET)影像表现。18F-氟多巴PET示尾状核头为著的摄取减低,18F-AV-45 PET示淀粉样蛋白沉积阴性、18F-AV-1451 PET示新皮质tau沉积,综合支持潜在的额颞叶变性-tau病理。Frontotemporal dementia(FTD)is a group of dementia diseases mainly characterized by progressive mental-behavioral abnormalities,executive dysfunction,and language impairment.A small number of FTD patients also present with movement disorders at certain disease course.Here the clinical and multimodal positron-emission tomography(PET)imaging manifestations in a patient with frontotemporal lobe dementia and parkinsonian syndrome are reported.18F-fluorodopa PET showed reduced uptake in the head of the caudate nucleus.18F-AV-45 PET showed negative amyloid deposition.18F-AV-1451 PET showed tau deposition in the neocortex.The clinical and neuroimaging features support the underlying frontotemporal lobar degeneration-tau pathology.

关 键 词：痴呆 正电子发射断层显像术 体层摄影术 X线计算机 帕金森综合征 tau蛋白病 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R749.1[医药卫生—临床医学]