多系统萎缩患者体位性低血压的危险因素分析  

Analysis of risk factors of orthostatic hypotension in patients with multiple system atrophy

作　　者：徐萱 王丽晔[2] 张新宁 黄晶晶 王垚 薛静 赵倩煜 陈志刚[2] XU Xuan;WANGLiye;ZHANG Xinning(The Second Clinical School of Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学第二临床医学院,100029 [2]北京中医药大学东方医院脑病一科 [3]西安市中医院脑病二科 [4]清华大学工程物理系 [5]北京市丰台中西医结合医院脑病科 [6]北京中医药大学第三附属医院医务处

出　　处：《临床神经病学杂志》2024年第5期330-335,共6页Journal of Clinical Neurology

基　　金：国家自然科学基金面上项目(8217152245);首都卫生发展科研专项项目(首发2018-2-4202);北京中医药大学校级项目(2020-JYB-ZDGG-119)。

摘　　要：目的探讨多系统萎缩(MSA)患者体位性低血压(OH)的危险因素。方法共纳入199例MSA患者,根据OH的严重程度将患者分组,比较各组间临床资料的差异,并用有序Logistic回归分析MSA患者出现OH的危险因素。结果不同OH等级患者在性别、糖尿病病史、疾病等级、晕厥、卧位高血压、疲劳、脑保护药物方面,差异有统计学意义(均P<0.05)。有序Logistic回归分析发现,疾病等级(很可能的MSA)、晕厥、卧位高血压、疲劳是MSA患者发生OH的独立危险因素(均P<0.05)。结论OH在MSA患者中普遍存在,其严重程度受多方面影响。其中疾病等级(很可能的MSA)、晕厥、卧位高血压、疲劳是MSA伴发OH的独立危险因素。Objective To explore the risk factors of orthostatic hypotension(OH)in patients with multiple system atrophy(MSA).Methods A total of 199 MSA patients were included,and they were divided into groups based on the severity of OH.The data differences between the groups were compared,and the risk factors for the occurrence of OH in MSA patients were analyzed from ordered Logistic regression.Results There were significant differences in gender,diabetes,disease grade,syncope,supine hypertension,fatigue and brain protective drugs among patients with different OH grades(all P<0.05).Ordered Logistic regression analysis found that disease grade(probable MSA),syncope,supine hypertension,and fatigue were independent risk factors for the occurrence of OH in MSA patients(all P<0.05).Conclusions OH is commonly present in MSA patients,and its severity is influenced by many factors.Disease grade(probable MSA),syncope,lying hypertension and fatigue are independent risk factors of OH in patients with MSA.

关 键 词：多系统萎缩 体位性低血压 临床特征 危险因素 

分 类 号：R741[医药卫生—神经病学与精神病学]