Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications  

作　　者：Jia Min Loh Yun Jie Larissa Lim Jin Ting Tay Hui Mei Cheng Hong Liang Tey Kun Liang 

机构地区：[1]A*STAR Skin Research Labs(A*SRL),Agency for Science,Technology and Research(A*STAR),Singapore [2]National Skin Centre(NSC),Singapore [3]Lee Kong Chian School of Medicine,Nanyang Technological University,Singapore [4]Yong Loo Ling School of Medicine,National University of Singapore,Singapore [5]Skin Research Institute of Singapore,Singapore

出　　处：《Bioactive Materials》2024年第2期222-241,共20页生物活性材料（英文）

基　　金：supported by the National Additive Manufacturing Innovative Cluster(NAMIC)POC Funding,Agency for Science,Technology and Research(A*STAR)Career Development Fund and BMRC Central Research Fund(CRF,ATR);NHG Medical Technologies&Innovations(CMTi)and National Health Innovation Centre Singapore(NHIC)Joint MedTech Grant.

摘　　要：Microneedles(MNs)is an emerging technology that employs needles ranging from 10 to 1000μm in height,as a minimally invasive technique for various procedures such as therapeutics,disease monitoring and diagnostics.The commonly used method of fabrication,micromolding,has the advantage of scalability,however,micromolding is unable to achieve rapid customizability in dimensions,geometries and architectures,which are the pivotal factors determining the functionality and efficacy of the MNs.3D printing offers a promising alternative by enabling MN fabrication with high dimensional accuracy required for precise applications,leading to improved performance.Furthermore,enabled by its customizability and one-step process,there is propitious potential for growth for 3D-printed MNs especially in the field of personalized and on-demand medical devices.This review provides an overview of considerations for the key parameters in designing MNs,an introduction on the various 3D-printing techniques for fabricating this new generation of MNs,as well as highlighting the advancements in biomedical applications facilitated by 3D-printed MNs.Lastly,we offer some insights into the future prospects of 3D-printed MNs,specifically its progress towards translation and entry into market.

关 键 词：MICRONEEDLES 3D printing Drug delivery Extraction of biological specimen BIOSENSING 

分 类 号：R318[医药卫生—生物医学工程]