氨磺必利与齐拉西酮治疗精神分裂症的临床疗效及其对心电图QTC间期的影响  

Clinical efficacy of amisulpride and ziprasidone in the treatment of schizophrenia and its effect on QTC interval of electrocardiogram

作　　者：郭亮 刘沛霖 钟清梅[1] GUO Liang;LIU Peilin;ZHONG Qingmei(Department of Psychiatry,Ji'an Third People's Hospital,Ji'an,Jiangxi,343000,China)

机构地区：[1]吉安市第三人民医院精神科,江西吉安343000

出　　处：《当代医学》2024年第19期46-50,共5页Contemporary Medicine

基　　金：江西省吉安市科技计划项目(吉市科计字〔2021〕8号114)。

摘　　要：目的观察氨磺必利与齐拉西酮治疗精神分裂症的临床疗效及对心电图QTC间期的影响。方法选取2020年5月至2022年8月吉安市第三人民医院收治的76例精神分裂症患者作为研究对象,采用随机数字表法分为常规组与研究组,各38例。常规组服用盐酸齐拉西酮胶囊,研究组服用氨磺必利。比较两组临床疗效、阳性和阴性症状量表(positive and negative syndrome scale,PANSS)评分、记忆功能[韦氏记忆量表中国修订版(Wechsler memory scale-revised Chinese version,WMS-RC)评分]、认知功能[简易智能精神状态检查量表(mini-mental state examination,MMSE)评分]、QTC间期及不良反应发生情况。结果两组治疗总有效率比较差异无统计学意义。用药后,两组一般精神病理、阳性症状、阴性症状评分及总分均低于用药前,差异有统计学意义(P<0.05),但组间比较差异无统计学意义。用药后,两组WMS-RC、MMSE评分均高于用药前,差异有统计学意义(P<0.05),但组间比较差异无统计学意义。用药后2、4、8周,研究组QTC间期均短于常规组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论氨磺必利、齐拉西酮治疗精神分裂症临床疗效及安全性相当,均可减轻患者阳性及阴性症状,改善患者记忆功能与认知功能,但氨磺必利对心电图QTC间期的影响更小,值得临床推广应用。Objective To observe the clinical efficacy of amisulpride and ziprasidone in the treatment of schizophrenia and its effect on QTC interval of electrocardiogram.Methods 76 patients with schizophrenia were treated in Ji'an Third People's Hospital from May 2020 to August 2022 were selected as the study subjects,they were divided into the conventional group and the study group according to random number table method,with 38 cases in each group.The conventional group was given ziprasidone hydrochloride capsules,the study group was given amisulpride.The clinical efficacy,positive and negative syndrome scale(PANSS)score,memory function(Wechsler memory scale-revised Chinese version[WMS-RC]score),cognitive function(mini-mental state examination[MMSE]score),QTC interval and the occurrence of adverse effects were compared between the two groups.Results There was no difference in the total treatment rate between the two groups.After medication,the general psychopathology,positive and negative symptom scores and total scores of the two groups were lower than those before medication,and the differences were statistically significant(P<0.05),but there was no significant difference between the two groups.After medication,the WMS-RC and MMSE scores of the two groups were higher than those before medication,and the differences were statistically significant(P<0.05),but there was no significant difference between the two groups.After 2,4,and 8 weeks of medication,the QTC interval in the study group were shorter than those in the conventional group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups.Conclusion Amisulpiride and ziprasidone are equally effective and safe in the treatment of schizophrenia,both of which can alleviate the positive and negative symptoms and improve the memory function and cognitive function of patients,but amisulpiride has less negative impact on QTC interval of ECG,it is worthy of clinica

关 键 词：精神分裂症 氨磺必利 齐拉西酮 QTC间期 

分 类 号：R749.3[医药卫生—神经病学与精神病学]