丙戊酸钠缓释片联合小剂量喹硫平在伴非自杀性自伤的青少年抑郁中的应用及安全性分析  

Application and safety analysis of sodium valproate sustained-release tablets combined with low-dose quetiapine in adolescent depression with non-suicidal self-injury

作　　者：谷光 郑力强 张莉莉 GU Guang;ZHENG Liqiang;ZHANG Lili(Department of Child and Adolescent Psychiatry,Fourth People's Hospital of Liaocheng City,Liaocheng,Shandong,252000,China)

机构地区：[1]聊城市第四人民医院儿童青少年精神科,山东聊城252000

出　　处：《当代医学》2024年第19期113-116,共4页Contemporary Medicine

摘　　要：目的探讨丙戊酸钠缓释片联合小剂量喹硫平在伴非自杀性自伤青少年抑郁治疗中的应用疗效及对患者用药安全性的影响。方法选取2020年12月至2022年7月聊城市第四人民医院治疗的100例非自杀性自伤青少年抑郁症患者作为研究对象,按照随机数字表法分为研究组与对照组,每组50例。对照组给予丙戊酸钠缓释片治疗,研究组采用丙戊酸钠缓释片联合小剂量喹硫平治疗,比较两组心理状态[汉密尔顿抑郁量表(Hamilton depression scale,HAMD)、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)]、非自杀性自伤行为发生情况、甲状腺激素[促甲状腺激素(thyroid stimulating hormone,TSH)、游离三碘甲状腺原氨酸(free triiodothyronine,FT3)、游离甲状腺素(free thyroxine,FT4)]水平、临床疗效及不良反应发生情况。结果治疗1、4、8周后,两组HAMD、HAMA评分均低于前一时间点,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗1周后,两组非自杀性自伤行为发生率比较差异无统计学意义;治疗4、8周后,研究组非自杀性自伤行为发生率低于对照组,差异有统计学意义(P<0.05)。治疗8周后,两组TSH水平均高于治疗前,FT3与FT4水平低于治疗前,差异有统计学意义(P<0.05)。研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论丙戊酸钠缓释片联合小剂量喹硫平治疗伴非自杀性自伤的青少年抑郁,可有效改善患者抑郁、焦虑症状,减少非自杀性自伤行为发生风险,安全性较高。Objective To investigate the efficacy of sodium valproate sustained-release tablets combined with low-dose quetiapine in the treatment of adolescents depression with non-suicidal self-injury and its effect on the safety of patients.Methods 100 non-suicidal self-injury adolescent depression patients treated in Fourth People's Hospital of Liaocheng City from December 2020 to July 2022 were selected as the research subjects,they were divided into the study group and the control group according to the random number table method,with 50 cases in each group.The control group was treated with sodium valproate sustained-release tablets,and the study group was treated with sodium valproate sustained-release tablets combined with low-dose quetiapine,the psychological status(Hamilton depression scale[HAMD],Hamilton anxiety scale[HAMA],non-suicidal self-injury behavior,thyroid hormone(thyroid stimulating hormone[TSH],free triiodothyronine[FT3],free thyroxine[FT4])levels,clinical efficacy and adverse reactions were compared between the two groups.Results After 1,4 and 8 weeks of treatment,the scores of HAMD and HAMA of the two groups were lower than those at the previous time point,and the study group was lower than the control group,the differences were statistically significant(P<0.05).After 1 week of treatment,there was no significant difference in the incidence of non-suicidal self-injury between the two groups;after 4 and 8 weeks of treatment,the incidence of non-suicidal self-injury in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).After 8 weeks of treatment,the levels of TSH in the two groups were higher than those before treatment,and the levels of FT3 and FT4 were lower than those before treatment,the differences were statistically significant(P<0.05).The total effective rate of treatment in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidenc

关 键 词：丙戊酸钠缓释片 喹硫平 青少年抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]