小G蛋白Rho家族与药物成瘾突触重塑  

Rho GTPase family in synaptic plasticity regulation of drug addiction

作　　者：薛涛 张璐 XUE Tao;ZHANG Lu(Department of pathophysiology,Key Laboratory of Functional Proteomics of Guangdong Province School of Basic Medical Sciences,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学基础医学院病理生理学教研室,广东省蛋白质组学重点实验室,广东广州510515

出　　处：《中国病理生理杂志》2024年第11期2145-2150,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.82471520,No.81971297,No.81571860,No.81430045,No.81472166);广东省基础与应用基础研究基金资助项目(No.2024A1515012512,No.2023A1515012480);教育部新世纪优秀人才支持计划(No.NCET-09-0088);广东省珠江学者人才项目(No.GDUPS2015)。

摘　　要：神经元突触重塑是神经系统结构与功能的适应性改变的能力,分为结构性突触重塑和功能性突触重塑,在脑功能生理状态和病理状态中起着重要作用。神经精神疾病的核心致病机制之一就是神经元突触重塑。小G蛋白Rho家族对神经元突触重塑具有重要的调控作用,其中Rac1、Cdc42和RhoA最为人熟知。本文总结了小G蛋白Rho家族在药物成瘾中对突触重塑的调控作用,以期加深对药物成瘾分子机制的理解。Neuronal synaptic plasticity involves adaptive changes in the structure and function of the nervous system,which can be categorized into structural and functional forms.This plasticity is crucial for both physiological and pathological brain states.The Rho GTPase family,comprising Rac1,Cdc42 and RhoA,plays distinct and significant roles in regulating neuronal synaptic plasticity.This review explores the influence of the Rho GTPase family on synaptic plasticity in drug addiction,thus enhancing our understanding of the molecular mechanisms underlying this condition.

关 键 词：药物成瘾 小G蛋白Rho家族 突触可塑性 

分 类 号：R74[医药卫生—神经病学与精神病学] R964[医药卫生—临床医学] R363.2