多聚磷酸盐的促凝血功能、机制及潜在应用  

Procoagulant role,mechanism and potential applications of inorganic polyphosphate

作　　者：陈琪邦 王嘉军 刘可云 石廷玉 CHEN Qibang;WANG Jiajun;LIU Keyun;SHI Tingyu(Medical School of Hubei Minzu University,Enshi 445000,China;Hubei Key Laboratory of Selenium Resources Research and Biological Applications,Enshi 445000,China)

机构地区：[1]湖北民族大学医学部,湖北恩施445000 [2]硒资源研究与生物应用湖北省重点实验室,湖北恩施445000

出　　处：《中国病理生理杂志》2024年第11期2151-2159,共9页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.82460396);国家自然科学基金青年基金资助项目(No.81801979);湖北省自然科学基金青年项目(No.2018CFB384);湖北民族大学大学生创新创业训练计划项目(No.202310517008)。

摘　　要：多聚磷酸盐(polyphosphate,polyP)广泛存在于生物界,并具有显著的促凝血活性。长链polyP(存在于微生物中)在病理生理条件下能够有效的激活接触途径,并触发血栓形成和炎症反应,表明以polyP作为靶标筛选的抑制剂可能作为新的抗血栓药物,并具有最小的出血副作用。短链polyP(来源于人类血小板)能够加速V因子的活化,完全废除组织因子途径抑制剂的抗凝血功能,增强纤维蛋白的结构并且能够加速凝血酶对XI因子的活化,表明polyP可以作为止血剂。本文详细阐述polyP调控血液凝固的作用、机制及筛选polyP抑制剂的策略。Inorganic polyphosphate(polyP)is wide spread in biology and exhibits striking procoagulant ef-fects in vivo.Long-chain polyphosphate(such as those present in infectious microorganisms)is a potent,natural patho-physiologic activator of the contact pathway of blood clotting and promotes thrombosis and inflammation,which suggest that antagonizing polyP function in vivo may be an attractive approach for identifying novel antithrombotic agents,perhaps with reduced bleeding side effects compared with conventional anticoagulant drugs.Short-chain polyphosphate(secreted from activated human platelets)remarkably accelerates factor V activation,absolutely abrogates the anticoagulant function of tissue factor pathway inhibitor,increase fibrin clot structure,and accelerates factor XI activation by thrombin.So polyP may be used as hemostatic agent.In this paper,the procoagulant role of polyP and the mechanism underlying polyP modu-lates blood clotting and the strategy of screening polyP inhibitors are described in detail.

关 键 词：多聚磷酸盐 止血 血栓形成 抗凝血 药物靶点 

分 类 号：R364.15[医药卫生—病理学] R552[医药卫生—基础医学] R973.2