神经胶质细胞的铁死亡  

Ferroptosis in glial cells

作　　者：王秋烜 冯婿洋 黄月 韩景献[1] 刘小溪[1] 张雪竹[1] WANG Qiuxuan;FENG Xuyang;HUANG Yue;HAN Jingxian;LIU Xiaoxi;ZHANG Xuezhu(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381;Tianjin Medical University,Tianjin 300070)

机构地区：[1]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津300381 [2]天津医科大学,天津300070

出　　处：《中国病理生理杂志》2024年第11期2166-2172,共7页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.30630074,No.82174492);天津市科技计划项目(No.20YFZCSY00810)。

摘　　要：铁死亡是一种新型的程序性细胞死亡方式,其依赖于细胞内铁离子的积累,通过大量的脂质过氧化对细胞膜造成不可修复的损伤,最终导致细胞死亡。铁死亡与多种神经退行性疾病密切相关。神经胶质细胞的铁死亡可以通过诱导神经炎症和调节氧化应激等途径来调控神经元死亡,从而促进神经退行性疾病的进展。本文综述了铁死亡在不同类型神经胶质细胞中的发生及其对神经元的影响,旨在深入理解神经胶质细胞铁死亡对神经退行性疾病的作用,并探索抑制这一过程在治疗中的潜在应用前景。Ferroptosis is a novel form of programmed cell death that relies on the accumulation of intracellular iron ions,causing irreversible damage to cell membranes through extensive lipid peroxidation,ultimately leading to cell death.Ferroptosis is closely associated with various neurodegenerative diseases.The ferroptosis of glial cells can regulate neuronal death by inducing neuroinflammation and affecting oxidative stress,thereby exacerbating the progression of neu-rodegenerative diseases.This review summarizes how ferroptosis occurs in different types of glial cells and its impact on neurons,aiming to deeply understand the effects of glial cell ferroptosis on neurodegenerative diseases and explore the po-tential therapeutic applications of inhibiting this process in treatment.

关 键 词：铁死亡 铁超载 氧化应激 神经胶质细胞 神经元 炎症 

分 类 号：Q421[生物学—神经生物学] R741.02[生物学—生理学] R363[医药卫生—神经病学与精神病学]