T1期结肠直肠癌淋巴结转移相关危险因素的研究进展  

Progress in research of the risk factors of lymph node metastasis in T1 stage colorectal cancer

作　　者：陈芳倩 冯雯卿(综述) 赵敬坤[1] 宗雅萍[1] 陆爱国(审校)[1] CHEN Fangqian;FENG Wenqing;ZHAO Jingkun;ZONG Yaping;LU Aiguo(Department of General Surgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院普外科,上海200025

出　　处：《外科理论与实践》2024年第4期358-364,共7页Journal of Surgery Concepts & Practice

摘　　要：结肠直肠癌是常见的消化道恶性肿瘤之一,随着筛查手段的普及与内镜技术的发展,越来越多T1期结肠直肠癌得以发现。准确预测其淋巴结转移风险,对指导临床治疗决策、降低并发症和死亡风险具有重要意义。目前对T1期结肠直肠癌淋巴结转移相关危险因素的研究涵盖临床病理特征、分子表型及遗传特征等多个方面。部分研究通过综合这些因素构建预测模型,其敏感性、特异性和准确率优于目前临床指南,对临床很有借鉴意义。Colorectal cancer is one of the common malignant tumors of the digestive tract.With the popularization of screening methods and advancement of endoscopic technology,an increasing number of T1 stage colorectal cancers can be discovered.Accurately predicting lymph node metastasis risk is significantly important for guiding clinical treatment decisions,reducing complications and mortality.Current research on risk factors for lymph node metastasis in T1 stage colorectal cancer covers multiple aspects including clinical pathological features,molecular phenotypes and genetic characteristics.Some studies have built prediction models by integrating these factors,which show higher sensitivity,specificity and accuracy compared to current clinical guidelines.These models provide valuable experience for clinical practice.

关 键 词：结肠直肠癌 淋巴结转移 肿瘤微环境 转录组 基因组 多模态模型 

分 类 号：R735.35[医药卫生—肿瘤] R735.37[医药卫生—临床医学]