胰胆管合流异常相关性胆囊癌研究进展  

Advances in research of pancreaticobiliary maljunction⁃associated gallbladder cancer

作　　者：马煜博 李起(综述) 张东[1] 耿智敏(审校)[1] MA Yubo;LI Qi;ZHANG Dong;GENG Zhimin(Department of Hepatobiliary Surgery,the First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院肝胆外科,陕西西安710061

出　　处：《外科理论与实践》2024年第4期365-369,共5页Journal of Surgery Concepts & Practice

基　　金：国家自然科学基金(62076194);陕西省重点研发计划项目(2021⁃SF⁃016,2022⁃SF⁃606)。

摘　　要：胰胆管合流异常(PBM)是一种先天性胰胆管畸形,常会引起反复发作的胆管炎、胰腺炎。越来越多的证据表明PBM是一种癌前病变,在胆囊癌(GBC)的发生和发展中起着重要的作用。由PBM所致GBC称为PBM相关性GBC。因此,PBM的早期识别及诊治对于降低GBC的风险至关重要。本文对PBM的概况和诊疗进展以及PBM相关性GBC的临床特征、发生机制及诊疗进展加以综述,旨在显示早期诊治PBM的临床价值,从而降低PBM相关性GBC发生率。Pancreatobiliary maljunction(PBM)represents a congenital anatomical abnormality of the pancreaticobiliary ductal system,frequently predisposing individuals to recurrent cholangitis and pancreatitis.Accumulating evidence indicates that PBM is a precancerous lesion,and PBM plays an important role in the development and progression of gallbladder cancer(GBC).GBC arising from PBM is designated as PBM⁃associated GBC.Consequently,early diagnosis and treatment of PBM is paramount in mitigating the risk of GBC.This review outlined the epidemiology and advancements in the diagnosis and management of PBM,along with the clinical features,underlying mechanisms,and therapeutic progressions pertaining to PBM⁃associated GBC,in order to underscore the clinical significance of early intervention in PBM,so as to reduce the incidence of PBM⁃associated GBC.

关 键 词：胰胆管合流异常 胆囊癌 胆道肿瘤 

分 类 号：R735.8[医药卫生—肿瘤] R657.4[医药卫生—临床医学] R657.5