Heterogeneity and clinical genomics of bla_(KPC-2)-producing,carbapenem-resistant Pseudomonas aeruginosa  

作　　者：Man Huang Lizhang Liu Xiaoxia Li Yu Shi Huimin Zhang Ting Lu Youjun Feng 

机构地区：[1]Key Laboratory of Multiple Organ Failure,Ministry of Education,Departments of Microbiology and General Intensive Care Unit of the Second Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang,China [2]Zhejiang Provincial Key Laboratory for Microbial Biochemistry and Metabolic Engineering,Zhejiang,China [3]Cancer Center at Illinois,University of Illinois at Urbana-Champaign,Illinois,USA [4]Department of Bioengineering,University of Illinois at Urbana-Champaign,Illinois,USA

出　　处：《hLife》2024年第6期314-319,共6页健康科学（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(32141001 and 31830001 to Y.F.);the National Science Fund for Distinguished Young Scholar(32125003 to Y.F.);the National Key Basic Research Program of China(2023YFC2307100 and 2023YFC2300021 to Y.F.).

摘　　要：Antimicrobial resistance(AMR)is one of the top global challenges of public health concern.In 2019,it was estimated that AMR claimed around 5 million deaths worldwide[1].Pseudomonas aeruginosa,which originated in soil and water,is recognized as an opportunistic pathogen causing recalcitrant infections.Carbapenem-resistant P.aeruginosa(CRPA)is listed by the World Health Organization(WHO)as an important member of top priority“ESKAPE”pathogens.This is largely supported by the fact that in 2020,CRPA had caused28,8000 nosocomial infections with about 2500 deaths.Apart from porin mutations,the acquisition of Klebsiella pneumoniae carbapenemase(termed as KPC-2)constitutes an alternative mechanism for carbapenem resistance in P.aeruginosa,which compromises the clinical efficacy of the carbapenem as a“last resort”option.Notably,the transferability of blaKPC-2 determinants facilitates global dissemination of CRPA in the context of“one health”consisting of humans,animals,plants/crops,and environmental settings.In addition to antimicrobial stewardship,coordinated global action is necessary to mitigate AMR progression.

关 键 词：KPC resistant RESORT 

分 类 号：R96[医药卫生—药理学]