点击化学在肿瘤研究中的应用  

Click Chemistry in Human Cancer Research

作　　者：张百红 岳红云 ZHANG Baihong;YUE Hongyun(Department of Oncology,940th Hospital of Joint Logistics Support Force of People's Liberation Army,Lanzhou 730050,China;Department of Ophthalmology,940th Hospital of Joint Logistics Support Force of People's Liberation Army,Lanzhou 730050,China)

机构地区：[1]解放军联勤保障部队第九四〇医院肿瘤科,兰州730050 [2]解放军联勤保障部队第九四〇医院眼科,兰州730050

出　　处：《肿瘤防治研究》2024年第11期951-955,共5页Cancer Research on Prevention and Treatment

基　　金：甘肃省自然科学基金(22JR5RA007);联勤保障部队第九四〇医院课题(2021yxky052)。

摘　　要：点击化学是最重要的生物正交化学反应,它像“乐高”一样将分子连接起来。点击化学正深刻影响着肿瘤研究,例如修饰肿瘤细胞、设计肿瘤药物、传输肿瘤药物、药物临床前评估和操控免疫细胞。点击化学也将被用于分子发现和靶向治疗,为肿瘤研究提供新方法。As one of the typical bioorthogonal chemistry reactions,click chemistry joins molecules similar to“Lego”.Bioorthogonal click chemistry is used to modify cancer cells,design antitumor drugs,delivery drugs,manipulate immune cells,and help preclinical evaluation.Click chemistry provides a promising approach for discovering molecules and targeting cancer in cancer research.

关 键 词：肿瘤 点击化学 生物正交化学 肿瘤研究 

分 类 号：R730.1[医药卫生—肿瘤]