Painful memories boost protective immunity  

作　　者：Tri Giang Phan Elissa K.Deenick 

机构地区：[1]Precision Immunology Program,Garvan Institute of Medical Research,Sydney,NSW,Australia [2]St Vincent’s Healthcare Clinical Campus,Faculty of Medicine and Health,UNSW Sydney,Sydney,NSW,Australia [3]Kirby Institute,Faculty of Medicine and Health,UNSW Sydney,Sydney,NSW,Australia.✉email:[e-mail]

出　　处：《Cell Research》2024年第11期751-752,共2页细胞研究（英文版）

基　　金：supported by NHMRC L2 Investigator grant ID 2026122;E.K.D.by NHMRC L2 Investigator grant ID 2026131.

摘　　要：How does pain,induced by inflammation,an innate immune response to tissue injury,impact humoral immunity,an adaptive immune response to infection?In a recent study in Cell,Wu et al.show that TRPV1+nociceptive sensory neurons detect the inflammatory lipid mediator PGE2 and release CGRP to activate the CALCRL/RAMP1 heterodimeric receptor,adenylate cyclase and cAMP signaling on B cells to boost the humoral immune response.

关 键 词：RELEASE IMMUNITY BOOST 

分 类 号：O62[理学—有机化学]