The role of SLC26A8 homozygous variants in male infertility and flagellum abnormalities  

作　　者：Bin Mao Sha-Sha Zhang Liang-Tao Zhao Hui-Rong Huang Feng-Die Ma Wen-Jing Shi Shan Li Zi-Yan Nie Han-Dan Xiao Xiao-Dong Xie Pei-Qiang Li 

机构地区：[1]Institute of Genetics,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China [2]The Reproductive Medicine Center,Lanzhou University First Hospital,Lanzhou 730000,China [3]School of Second Clinical Medicine,Lanzhou University Second Hospital,Lanzhou 730030,China

出　　处：《Asian Journal of Andrology》2024年第5期544-546,共3页亚洲男性学杂志（英文版）

基　　金：support from grants provided by the Gansu Provincial Natural Science Foundation of China(23JRRA1046);the Gansu Association for Science and Technology(GSHZTS 2022-04);the National College Student Innovation and Entrepreneurship Training Program(202310730222).

摘　　要：Dear Editor,Solute carrier family 26 member 8(SLC26A8)gene belongs to the solute carrier 26(SLC26)family.It demonstrates distinct expression in male spermatozoa.This gene potentially plays a role in the formation of the sperm annulus,a circular structure linking the midpiece and principal piece of mature sperm flagella.1 Studies in mice have shown that the deficiency of Slc26A8 leads to compromised sperm motility,capacitation,and structural anomalies.These include disarray in the mitochondrial sheath,abnormalities in the annulus,and bending of the flagella.2,3 Nevertheless,our comprehension of SLC26A8 mutations in male infertility is still restricted,with only a limited number of studies addressing this aspect.4-6 Therefore,further research is crucial to elucidate the functional significance of mutations in SLC26A8.

关 键 词：INFERTILITY SLC linking 

分 类 号：R698.2[医药卫生—泌尿科学]