精神分裂症的候选遗传标志物研究进展  

Advances in candidate genetic biomarkers in schizophrenia

作　　者：贺静琦 何张崟 李锦光 唐劲松 He Jingqi;He Zhangyin;Li Jinguang;Tang Jinsong(Department of Psychiatry,Sir Run-Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310018,China;Department of Psychiatry,National Clinical Research Center for Mental Disorders,and National Center for Mental Disorders,the Second Xiangya Hospital of Central South University,Changsha 410011,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院精神卫生科,杭州310018 [2]中南大学湘雅二医院精神科、国家精神疾病医学中心、国家精神心理疾病临床医学研究中心,长沙410011

出　　处：《中华精神科杂志》2024年第11期758-765,共8页Chinese Journal of Psychiatry

基　　金：国家重点研发计划(2022YFE0103700);国家自然科学基金(82171495)。

摘　　要：精神分裂症是一种严重的高致残精神障碍,发病机制复杂且尚不明确,临床上仍缺乏客观的诊疗指标。大量证据表明,遗传因素对精神分裂症的发生与转归至关重要,遗传相关标志物颇具应用前景。本文围绕精神分裂症的候选遗传学生物标志物相关研究进行综述,以期为精神分裂症的精准诊疗提供参考。Schizophrenia is a serious and highly disabling mental disorder,its pathogenesis is complex and unclear,and there is still a lack of objective clinical diagnosis and treatment indicators.A large amount of evidence had shown that genetic factors play important roles in the development and prognosis of schizophrenia,and genetic-related markers have great application prospects.This paper reviews the research on candidate genetic biomarkers of schizophrenia in order to provide reference for the precise diagnosis and treatment of schizophrenia.

关 键 词：精神分裂症 遗传标记 表观遗传 

分 类 号：R749.3[医药卫生—神经病学与精神病学]