肺癌术后化疗患者血浆D-二聚体水平与癌因性疲乏及生活质量的关系研究  

Relationship between plasma D-dimer level and cancer-induced fatigue and quality of life in patients with lung cancer undergoing chemotherapy

作　　者：王瑾[1] 铁小伟 付宝宝 Wang Jin;Tie Xiaowei;Fu Baobao(Department of Oncology,The First Hospital of Anhui University of Science and Technology,Huainan 232001,Anhui Province,China)

机构地区：[1]安徽理工大学第一附属医院肿瘤内科,淮南232001

出　　处：《中国基层医药》2024年第11期1607-1611,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：安徽省淮南市科技计划(淮科规2022-72);安徽理工大学2023年度医学专项培育项目(2023-28)。

摘　　要：目的分析肺癌术后化疗患者血浆D-二聚体水平与癌因性疲乏及生活质量的关系。方法采用横断面研究,选取2020年1月至2023年12月在安徽理工大学第一附属医院化疗的ⅠB~ⅢA期肺癌术后患者58例纳入观察组,选取同期确诊为肺癌已完成辅助化疗进入随访阶段的患者41例为对照组。观察组于术后辅助化疗前、化疗4个周期后检测血浆D-二聚体水平,对照组于随访前、随访3个月检测血浆D-二聚体水平。采用中文版癌因性疲乏量表和中文版肺癌患者生活质量测定量表(FACT-L)评估两组患者的癌因性疲乏程度和生活质量。采用Pearson相关性评估血浆D-二聚体水平与癌因性疲乏及生活质量的关系。结果化疗4个周期后/随访3个月,观察组血浆D-二聚体为(1.17±0.32)mg/L,高于对照组的(0.66±0.29)mg/L(t=-8.26,P<0.001)。观察组化疗后中文版癌因性疲乏量表评分为(79.82±9.74)分,高于对照组的(67.49±8.12)分(t=-6.85,P<0.001)。观察组FACT-L中肿瘤相关症状、生理状况、社会/家庭状况、功能情况、情感状况评分分别为(21.26±3.17)分、(14.37±2.24)分、(22.63±3.48)分、(11.53±2.13)分、(14.79±2.73)分,均低于对照组的(22.42±3.31)分、(17.65±2.64)分、(25.12±3.39)分、(16.34±2.68)分、(16.37±2.76)分,差异均有统计学意义(t=3.26、6.48、3.56、3.60、2.82,均P<0.05)。Pearson相关性分析显示,血浆D-二聚体水平与癌因性疲乏量表评分呈正相关(r=0.367,P<0.001),与FACT-L总分呈负相关(r=-0.334,P<0.001)。结论IB-ⅢA期肺癌术后患者在接受辅助化疗过程中,血浆D-二聚体水平的变化与癌因性疲乏的程度相关,且对生活质量有影响,监测血浆D-二聚体水平可作为评估化疗影响及指导临床治疗的重要参考。Objective To analyze the relationship between plasma D-dimer level and cancer-related fatigue and quality of life in patients with lung cancer after chemotherapy.Methods A cross-sectional study was conducted involving 58 patients with stageⅠB-ⅢA lung cancer who received chemotherapy at The First Hospital of Anhui University of Science and Technology from January 2020 to December 2023.These patients comprised the observation group.The control group consisted of 41 patients diagnosed with lung cancer who had completed adjuvant chemotherapy and entered the follow-up stage.The plasma D-dimer level in the observation group was monitored before and after four cycles of postoperative adjuvant chemotherapy.The plasma D-dimer level in the control group was monitored before and after 3 months of follow-up.The Chinese version of the Cancer Fatigue Scale and the Chinese version of the Functional Assessment of Cancer Therapy-Lung(FACT-L)were used to evaluate cancer-related fatigue levels and quality of life in both groups.Pearson correlation analysis was performed to assess the relationship between plasma D-dimer levels and cancer-related fatigue and quality of life.Results After four cycles of chemotherapy and 3 months of follow-up,the plasma D-dimer level in the observation group was significantly higher than that in the control group[(1.17±0.32)mg/L vs.(0.66±0.29)mg/L,t=-8.26,P<0.001].The score of the Chinese version of the FACT-L in the observation group was significantly higher than that in the control group[(79.82±9.74)points vs.(67.49±8.12)points,t=-6.85,P<0.001].The scores for tumor-related symptoms,physiological status,social/family status,functional status,and emotional status in the FACT-L for the observation group were(21.26±3.17)points,(14.37±2.24)points,(22.63±3.48)points,(11.53±2.13)points,and(14.79±2.73)points,which were significantly lower than those in the control group[(22.42±3.31)points,(17.65±2.64)points,(25.12±3.39)points,(16.34±2.68)points,(16.37±2.76)points,t=3.26,6.48,3.56,3.60,2.82,

关 键 词：肺肿瘤 手术后期间 维持化疗 疲劳综合征 慢性 生活质量 病例对照研究 

分 类 号：R734.2[医药卫生—肿瘤]