Molecular structure and application of covalent organic frameworks(COFs)in tumor therapy  

作　　者：Junlin Li Yuanfeng Ye Yudi Peng Xiaoyun Hu Fanjiao Chen Yifan Zhang Shengchen Wang Suli Liu Dingsheng Wang Zhihui Dai 

机构地区：[1]Nanjing Key Laboratory of Optometric Materials and Technology,School of Materials and Engineering,Jinling Institute of Technology,Nanjing 211169,China [2]School of Chemistry and Molecular Engineering,Nanjing Tech University,Nanjing 211816,China [3]Department of Chemistry,Tsinghua University,Beijing 100022,China

出　　处：《National Science Open》2024年第6期68-99,共32页国家科学进展（英文）

基　　金：supported by the National Natural Science Foundation of China(22234005 and 21974070);the Natural Science Foundation of Jiangsu Province(BK20222015);the Young Academic Leaders of the Qing Lan Project of Jiangsu Province(SUJIAOSHIHAN[2022]No.29);the Industry-University-Research Cooperation Program of Jiangsu Province(BY20230054).

摘　　要：The field of nanomedicine has emerged as a vital component in cancer treatment modalities over the past decades.Covalent organic frameworks(COFs)at the nanoscale have become a novel and promising category of biomaterials in the field of nanomedicine.Their distinctive properties,such as low density,exceptional porosity,crystalline structure,remarkable thermal stability,versatile functionality,and biocompatibility,contribute to their significant potential in cancer therapy applications.This review firstly discusses COFs with various morphologies in theranostic applications.The primary morphologies of COFs for tumors treatment can be categorized into four types:nanospheres,nanosheets,nano-rods/tubes and nanoparticles.Furthermore,we review recent research articles and systematically discuss recent advancements in COFs for chemotherapy,chemodynamic therapy,photodynamic therapy,photothermal therapy and combination therapy.In conclusion,we outline the current obstacles and potential future directions for this distinctive research area.

关 键 词：covalent organic frameworks photodynamic therapy photothermal therapy combinatorial therapy 

分 类 号：R730.5[医药卫生—肿瘤] TB34[医药卫生—临床医学]