Vancomycin-encapsulated hydrogel loaded microarc-oxidized 3D-printed porous Ti6Al4V implant for infected bone defects:Reconstruction,anti-infection,and osseointegration  

作　　者：Teng Zhang Wenhao Zhou Wanliang Yang Jingwei Bi Hao Li Xianlei Gao Baoliang Zhang Guidong Shi Ka Li Zhijian Wei Xin Pan Shiqing Feng 

机构地区：[1]Department of Orthopedics,Qilu Hospital of Shandong University,Jinan,250012,China [2]Shaanxi Key Laboratory of Biomedical Metallic Materials,Northwest Institute for Non-ferrous Metal Research,Xi’an,710016,China [3]International Cooperation Base of Spinal Cord Injury,Tianjin Key Laboratory of Spine and Spinal Cord Injury,Department of Orthopedics,Tianjin Medical University General Hospital,Tianjin,China

出　　处：《Bioactive Materials》2024年第12期18-31,共14页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China[grant number 82202729];the Natural Science Foundation of Shandong Province[grant number ZR2022QH261];the Taishan Scholar Project of Shandong Province[grant number tsqn202306355];the National Natural Science Foundation of China[grant number 32101087];the Tianjin Municipal Science and Technology Program(21JCZDJC01100).

摘　　要：Infected bone defect is a formidable clinical challenge.Conventional approaches to prevention and treatment for infected bone defects are unsatisfactory.The key elements of the treatment are bone defect reconstruction,antiinfection,and osteogenesis.Conventional treatment methods remain unsatisfactory owing to the absence of composite integrating materials with anti-infective,and osteogenic activities as well as proper mechanical strength at the same time.In this study,we fabricated a vancomycin-encapsulated hydrogel with bacteriaresponsive release properties combined with a shaved porous(submicron-micron)three-dimensional-printed Ti6Al4V implant.The implant surface,modified with submicron-sized pores through microarc oxidation(MAO),showed enhanced osteogenic activity and integrated well with the hydrogel drug release system,enabling sustained vancomycin release.In vitro experiments underscored the commendable antibacterial ability,biosafety,and osteoinductive potential.Effective antibacterial and osteogenic abilities of the implant were further demonstrated in vivo in infected rabbit bone defects.These results showed that the vancomycinencapsulated hydrogel-loaded microarc-oxidized 3D-printed porous Ti6Al4V can repair the infected bone defects with satisfactory anti-infection and osseointegration effects.

关 键 词：Porous Ti6Al4V implants Infected bone defects ANTI-INFECTION OSSEOINTEGRATION 

分 类 号：TQ427.26[化学工程] R318[医药卫生—生物医学工程]