Monascus pigment-protected bone marrow-derived stem cells for heart failure treatment  

作　　者：Tian Yue Wentai Zhang Haifeng Pei Dunzhu Danzeng Jian He Jiali Yang Yong Luo Zhen Zhang Shiqiang Xiong Xiangbo Yang Qisen Ji Zhilu Yang Jun Hou 

机构地区：[1]Department of Cardiology,The Third People’s Hospital of Chengdu/Affiliated Hospital of Southwest Jiaotong University,Chengdu Institute of Cardiovascular Disease,Chengdu,Sichuan,610031,China [2]Dongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine,The Tenth Affiliated Hospital,Southern Medical University,Dongguan,Guangdong,523000,China [3]Department of Cardiology,The General Hospital of Western Theater Command,Chengdu,Sichuan,610083,China [4]School of Medicine,Tibet University,Lhasa,Tibet,850000,China [5]Ya’an Xunkang Pharmaceutical Co.,LTD,Ya’an,Sichuan,625015,China

出　　处：《Bioactive Materials》2024年第12期270-283,共14页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(81900339,82072072,32261160372);The Third People’s Hospital of Chengdu First-Class Incubation Project(CSY-YN-01-2023-003);Special Funding for Postdoctoral Research in Sichuan Province(2023TB095);The Fundamental Research Funds for the Central Universities(2682022TPY052);Chengdu Medical Research Project(2022138);the Natural Science Foundation of Tibet Autonomous Region Grant number(XZ202201ZR0036G).

摘　　要：Mesenchymal stem cells(MSCs)have demonstrated significant therapeutic potential in heart failure(HF)treatment.However,their clinical application is impeded by low retention rate and low cellular activity of MSCs caused by high inflammatory and reactive oxygen species(ROS)microenvironment.In this study,monascus pigment(MP)nanoparticle(PPM)was proposed for improving adverse microenvironment and assisting in transplantation of bone marrow-derived MSCs(BMSCs).Meanwhile,in order to load PPM and reduce the mechanical damage of BMSCs,injectable hydrogels based on Schiff base cross-linking were prepared.The PPM displays ROS-scavenging and macrophage phenotype-regulating capabilities,significantly enhancing BMSCs survival and activity in HF microenvironment.This hydrogel demonstrates superior biocompatibility,injectability,and tissue adhesion.With the synergistic effects of injectable,adhesive hydrogel and the microenvironment-modulating properties of MP,cardiac function was effectively improved in the pericardial sac of rats.Our results offer insights into advancing BMSCs-based HF therapies and their clinical applications.

关 键 词：BMSCS Monascus pigment Heart failure HYDROGEL MICROENVIRONMENT 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学] R541.6[医药卫生—基础医学]