Peptide nanozymes:An emerging direction for functional enzyme mimics  

作　　者：Shaobin He Long Ma Qionghua Zheng Zhuoran Wang Wei Chen Zihang Yu Xiyun Yan Kelong Fan 

机构地区：[1]CAS Engineering Laboratory for Nanozyme,Key Laboratory of Biomacromolecules(CAS),CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing,100101,China [2]Nanozyme Laboratory in Zhongyuan,Henan Academy of Innovations in Medical Science,Zhengzhou,Henan,451163,China [3]Laboratory of Clinical Pharmacy,Department of Pharmacy,The Second Affiliated Hospital of Fujian Medical University,Quanzhou,362000,China [4]Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province,Department of Pharmaceutical Analysis,Fujian Medical University,Fuzhou,350004,China [5]Department of Biomedical Engineering,Hajim School of Engineering&Applied Sciences,University of Rochester,Rochester,14627,USA

出　　处：《Bioactive Materials》2024年第12期284-298,共15页生物活性材料（英文）

基　　金：funded by the Key Project of the Joint Fund for Regional Innovation and Development of the National Natural Science Foundation of China(U23A20686);the Key Laboratory of Biomacromolecules,Chinese Academy of Sciences(ZGD-2023-03);the Joint Funds for the Innovation of Science and Technology,Fujian Province(2023Y9226);the Introduced High-Level Talent Team Project of Quanzhou City(2023CT008).

摘　　要：The abundance of molecules on early Earth likely enabled a wide range of prebiotic chemistry,with peptides playing a key role in the development of early life forms and the evolution of metabolic pathways.Among peptides,those with enzyme-like activities occupy a unique position between peptides and enzymes,combining both structural flexibility and catalytic functionality.However,their full potential remains largely untapped.Further exploration of these enzyme-like peptides at the nanoscale could provide valuable insights into modern nanotechnology,biomedicine,and even the origins of life.Hence,this review introduces the groundbreaking concept of“peptide nanozymes(PepNzymes)”,which includes single peptides exhibiting enzyme-like activities,peptide-based nanostructures with enzyme-like activities,and peptide-based nanozymes,thus enabling the investigation of biological phenomena at nanoscale dimensions.Through the rational design of enzyme-like peptides or their assembly with nanostructures and nanozymes,researchers have found or created PepNzymes capable of catalyzing a wide range of reactions.By scrutinizing the interactions between the structures and enzyme-like activities of PepNzymes,we have gained valuable insights into the underlying mechanisms governing enzyme-like activities.Generally,PepNzymes play a crucial role in biological processes by facilitating small-scale enzyme-like reactions,speeding up molecular oxidation-reduction,cleavage,and synthesis reactions,leveraging the functional properties of peptides,and creating a stable microenvironment,among other functions.These discoveries make PepNzymes useful for diagnostics,cellular imaging,antimicrobial therapy,tissue engineering,anti-tumor treatments,and more while pointing out opportunities.Overall,this research provides a significant journey of PepNzymes’potential in various biomedical applications,pushing them towards new advancements.

关 键 词：PEPTIDE Nanozyme Enzyme mimic Structure-activity relationship Biomedical applications 

分 类 号：O62[理学—有机化学]