Mg-gallate metal-organic framework-based sprayable hydrogel for continuously regulating oxidative stress microenvironment and promoting neurovascular network reconstruction in diabetic wounds  

作　　者：Chenxi Lian Jiawei Liu Wenying Wei Xiaopei Wu Takashi Goto Haiwen Li Rong Tu Honglian Dai 

机构地区：[1]State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,Wuhan University of Technology,Wuhan,430070,China [2]National Energy Key Laboratory for New Hydrogen-ammonia Energy Technologies,FoshanXianhu Laboratory,Foshan,528200,China [3]Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory,Chaozhou 521000,China

出　　处：《Bioactive Materials》2024年第8期181-194,共14页生物活性材料（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(52372272,32201109,32360234);the National Key Research and Development Program of China(2022YFB4601402);the Guangdong Basic and Applied Basic Research Foundation(2022B1515120052,2021A1515110557);the Key Basic Research Program of Shenzhen(JCYJ20200109150218836);the Self-innovation Research Funding Project of Hanjiang Laboratory(HJL202202A002).The authors thank the help of Tong Qiu,Qinghua Hou and Ran Yu of the Wuhan University of Technology,Wuhan 430070,China.

摘　　要：Chronic diabetic wounds are the most common complication for diabetic patients.Due to high oxidative stress levels affecting the entire healing process,treating diabetic wounds remains a challenge.Here,we present a strategy for continuously regulating oxidative stress microenvironment by the catalyst-like magnesium-gallate metal-organic framework(Mg-GA MOF)and developing sprayable hydrogel dressing with sodium alginate/chitosan quaternary ammonium salts to treat diabetic wounds.Chitosan quaternary ammonium salts with antibacterial properties can prevent bacterial infection.The continuous release of gallic acid(GA)effectively eliminates reactive oxygen species(ROS),reduces oxidative stress,and accelerates the polarization of M1-type macrophages to M2-type,shortening the transition between inflammation and proliferative phase and maintaining redox balance.Besides,magnesium ions adjuvant therapy promotes vascular regeneration and neuronal formation by activating the expression of vascular-associated genes.Sprayable hydrogel dressings with antibacterial,antioxidant,and inflammatory regulation rapidly repair diabetic wounds by promoting neurovascular network reconstruction and accelerating re-epithelialization and collagen deposition.This study confirms the feasibility of catalyst-like MOF-contained sprayable hydrogel to regulate the microenvironment continuously and provides guidance for developing the next generation of non-drug diabetes dressings.

关 键 词：Chronic diabetic wounds Bioactive MOF ANTIOXIDANT ANTI-INFLAMMATION Enzymatic catalysis Neurovascular network reconstruction 

分 类 号：R318[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]