Bioresponsive and transformable coacervate actuated by intestinal peristalsis for targeted treatment of intestinal bleeding and inflammation  

作　　者：Yuqi Peng Xiaofen Luo Xinyu Wang c Enling Hu Ruiqi Xie Fei Lu Weiwei Ding Fangyin Dai Guangqian Lan 

机构地区：[1]State Key Laboratory of Silkworm Genome Biology,College of Sericulture,Textile and Biomass Sciences,Southwest University,Chongqing,400715,China [2]Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile,Chongqing,400715,China [3]Division of Trauma and Surgical Intensive Care Unit,Research Institute of General Surgery,Jinling Hospital,Medical School of Nanjing University,Nanjing,210002,Jiangsu Province,China [4]School of Engineering,University of Birmingham,Edgbaston,Birmingham,UK

出　　处：《Bioactive Materials》2024年第11期627-639,共13页生物活性材料（英文）

基　　金：Chongqing Postdoctoral International Exchange Training Program(7820100997);Fundamental Research Funds for Central Universities(Nos.SWU-XDPY22010);National College Students Innovation and Entrepreneurship Training Program(202310635114);National Natural Science Foundation of China(No.81703424);Chongqing Graduate Student Research Innovation Project(CYB21121).

摘　　要：Developing an oral in situ-forming hydrogel that targets the inflamed intestine to suppress bleeding ulcers and alleviate intestinal inflammation is crucial for effectively treating ulcerative colitis(UC).Here,inspired by sandcastle worm adhesives,we proposed a water-immiscible coacervate(EMNs-gel)with a programmed coacervate-to-hydrogel transition at inflammatory sites composed of dopa-rich silk fibroin matrix containing embedded inflammation-responsive core-shell nanoparticles.Driven by intestinal peristalsis,the EMNs-gel can be actuated forward and immediately transform into a hydrogel once contacting with the inflamed intestine to yield strong tissue adhesion,resulting from matrix metalloproteinases(MMPs)-triggered release of Fe3+from embedded nanoparticles and rearrangement of polymer network of EMNs-gel on inflamed intestine surfaces.Extensive in vitro experiments and in vivo UC models confirmed the preferential hydrogelation behavior of EMNs-gel to inflamed intestine surfaces,achieving highly effective hemostasis,and displaying an extended residence time(48 h).This innovative EMNs-gel provides a non-invasive solution that accurately suppresses severe bleeding and improves intestinal homeostasis in UC,showcasing great potential for clinical applications.

关 键 词：Intestinal ulcer bleeding Bioadhesive coacervate Intestinal peristalsis drive Bioresponsive transformation Adhesive hydrogel 

分 类 号：R574[医药卫生—消化系统]