不同剂量阿托伐他汀联合阿司匹林对急性脑梗死患者脑血流指标以及颈动脉粥样斑块的影响研究  

Effects of Different Doses of Atorvastatin Combined with Aspirin on Cerebral Blood Flow Indexes and Carotid Atherosclerotic Plaque in Patients with Acute Cerebral Infarction

作　　者：黄宏 HUANG Hong(Yunxi County People's HospitalNeurology Department,Shiyan 442600,china)

机构地区：[1]郧西县人民医院神经内科,湖北十堰442600

出　　处：《中华灾害救援医学》2024年第9期1042-1044,1048,共4页Chinese Journal of Disaster Medicine

摘　　要：目的观察对急性脑梗死(Acute Cerebral Infarction,ACI)患者实施不同剂量阿托伐他汀联合阿司匹林治疗的临床效果。方法选取2021年11月至2024年1月临床确诊的急性脑梗死患者110例,按随机数字分组法分为高剂量组和低剂量组,每组55例,其中高剂量组给予阿司匹林联合40 mg/d阿托伐他汀治疗,低剂量组给予相同剂量阿司匹林联合20 mg/d阿托伐他汀治疗。结果治疗后两组脑血管床特性阻抗、外周阻力均低于本组治疗前,平均血流速度与平均血流量均高于治疗前(P<0.05)。治疗后颈动脉超声检测结果显示高剂量组的颈动脉内膜-中层厚度与斑块面积均明显小于低剂量组(P<0.05)。治疗前后的组内比较证实,两组颈动脉内膜-中层厚度明显下降,斑块面积均显著缩小(P<0.05)。治疗后两组神经功能缺损评分均显著下降(P<0.05),但治疗后两组评分间差异不明显(P>0.05)。结论对急性脑梗死患者实施高剂量阿托伐他汀联合阿司匹林可以更好地缩小颈动脉粥样斑块,但在改善脑血流指标方面的效果与低剂量阿托伐他汀联合阿司匹林无明显差异。Objective To observe the clinical effect of different doses of atorvastatin combined with aspirin in patients with acute cerebral infarction.Methods A total of 110 clinically confirmed cases of acute cerebral infarction from November 2021 to January 2024 were collected and divided into high-dose group and low-dose group according to random number grouping,with 55 cases in each group.The high-dose group was treated with aspirin combined with 40 mg/d atorvastatin.The low-dose group was given the same dose of aspirin combined with 20 mg/d atorvastatin.Results After treatment,the characteristic impedance and peripheral resistance of cerebral vascular bed in two groups were lower than before treatment,and the average blood flow velocity and average blood flow were higher than before treatment(P<0.05).The results of carotid ultrasound after treatment showed that the carotid intima-media thickness and plaque area in the high-dose group were significantly lower than those in the low-dose group(P<0.05).Intra-group comparison before and after treatment confirmed that carotid intima-media thickness decreased significantly and plaque area decreased significantly in both groups(P<0.05).After treatment,the scores of neurological impairment in both groups were significantly decreased(P<0.05),but there was no significant difference between the two groups after treatment(P>0.05).Conclusion High-dose atorvastatin combined with aspirin in patients with acute cerebral infarction can better reduce the carotid atherosclerosis plaque in patients,but the effect of improving cerebral blood flow indexes is not significantly different from that of low-dose atorvastatin combined with aspirin.

关 键 词：脑梗死 颈动脉血栓形成 治疗 临床研究性 

分 类 号：R741[医药卫生—神经病学与精神病学]