Single-cell transcriptomic atlas reveals immune and metabolism perturbation of depression in the pathogenesis of breast cancer  

作　　者：Lingling Wu Junwei Liu Yimeng Geng Jianwen Fang Xingle Gao Jianbo Lai Minya Yao Shaojia Lu Weiwei Yin Peifen Fu Wei Chen Shaohua Hu 

机构地区：[1]Department of Psychiatry,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,P.R.China [2]Department of Psychology,Children’s Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,P.R.China [3]Key Laboratory for Biomedical Engineering of the Ministry of Education,College of Biomedical Engineering and Instrument Science,Zhejiang University,Hangzhou,Zhejiang,P.R.China [4]Guangzhou National Laboratory,Guangzhou,Guangdong,P.R.China [5]Department of Breast Surgery,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,P.R.China [6]Department of Cardiology of The Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,Zhejiang,P.R.China [7]School of Basic Medical Science,Zhejiang University,Hangzhou,Zhejiang,P.R.China [8]The Key Laboratory of Mental Disorder’s Management in Zhejiang Province,Hangzhou,Zhejiang,P.R.China [9]Brain Research Institute of Zhejiang University,Hangzhou,Zhejiang,P.R.China [10]Zhejiang Engineering Center for Mathematical Mental Health,Hangzhou,Zhejiang,P.R.China [11]Department of Neurobiology,National Health Commission and Chinese Academy of Medical Sciences Key Laboratory of Medical Neurobiology,School of Brain Science and Brian Medicine,and Ministry of Education Frontier Science Center for Brain Science and Brain-machine Integration,Zhejiang University School of Medicine,Hangzhou,Hangzhou,Zhejiang,P.R.China

出　　处：《Cancer Communications》2024年第11期1311-1315,共5页癌症通讯（英文）

基　　金：supported by funding from the Zhejiang Provincial Key Research and Development Program(No.2021C03107 to S.H.);the Leading Talent of Scientific and Technological Innovation-“Ten Thousand Talents Program”of Zhejiang Province(No.2021R52016 to S.H.);the National Natural Science Foundation(No.82172770 to P.F.);the Fundamental Research Funds for the Central Universities(226-2022-00193,226-2022-00002).

摘　　要：Epidemiological evidence indicates that major depressive disorder(MDD)may predispose the development and prognosis of breast cancer(BC)in females[1].However,the mechanisms linking these phenotypes are not fully understood.Chronic stress,a hallmark of depression,has been underscored to affect anti-tumor immunity,tumor metabolic reprogramming,hormone synthesis in BC[2,3],and increase tumor metastasis[4],but there is a lack of detailed cellular-level characterization of how MDD history affects the tumorigenesis of BC.This study explored the single-cell atlas of multiple tissues from BC patients with and without a history of MDD for characterizing the potential molecular alternations in their tumorigenesis(Figure 1A).

关 键 词：METABOLISM immunity breast 

分 类 号：R730.3[医药卫生—肿瘤]