NO inhibitory constituents from Glycosmis craibii var.glabra  

作　　者：CHEN Hongwei DING Meng LIN Jun YUAN Shuo ZENG Kewu TU Pengfei JIANG Yong 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China

出　　处：《Chinese Journal of Natural Medicines》2024年第11期1040-1046,共7页中国天然药物（英文版）

基　　金：supported by National Natural Science Foundation of China(Nos.81973199,82173949,and 81773864);the Key Research and Development Project of Shandong Province(No.2021CXGC010507)。

摘　　要：Six novel compounds,comprising three quinolones(1a,1b,and 2)and three flavanones(3-5),along with seven known analogs(6-13),were isolated from the 95%EtOH extract of the stems and leaves of Glycosmis craibii var.glabra.The structures of the new compounds were elucidated using HR-ESI-MS,UV,and 1D and 2D nuclear magnetic resonance(NMR)data analysis.The ab-solute configurations were determined through Mosher ester and electronic circular dichroism(ECD)spectral analysis.Compounds 2,6,9,and 10 demonstrated inhibition of nitric oxide(NO)production stimulated by lipopolysaccharide in BV-2 microglial cells,with IC50 values ranging from 13.5 to 20.1 μmol·L^(-1),comparable to the positive control,dexamethasone.

关 键 词：Glycosmis craibii var.glabra QUINOLONE FLAVANONE NO inhibition 

分 类 号：R917[医药卫生—药物分析学]