Pd(Ⅱ)/N,N0-Disulfonyl bisimidazoline-catalyzed asymmetric arylation of isoquinoline-1,3,4-trione-derived ketimines  

作　　者：An-Qi Miao Yu-Xin Wang Lin-Lin Xu Wen-Juan Hao Shu-Jiang Tu Jin-Peng Zhang Bo Jiang 

机构地区：[1]School of Chemistry&Materials Science,Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials,Jiangsu Normal University,Xuzhou 221116,China [2]Key Laboratory of Human Genetics and Environmental Medicine,College of Public Health,Xuzhou Medical University,Xuzhou 221004,China

出　　处：《Green Synthesis and Catalysis》2024年第3期165-169,共5页绿色合成与催化（英文）

基　　金：grateful for financial support from the National Natural Science Foundation of China(Nos.21971090 and 22271123);the Top-Notch Academic Programs Project of Jiangsu Higher Education Institution(TAPP).

摘　　要：A palladium/chiral N,N0-disulfonyl bisimidazoline(Bim)-catalyzed asymmetric addition of arylboronic acids to isoquinoline-1,3,4-trione-derived ketimines is reported,leading to the generation of a series of functionalized isoquinoline-1,3(2H,4H)-diones bearing one quaternary carbon-amino functionality in good to excellent yields with95%ee in most cases.The reaction has remarkable compatibility with both substrate scopes,providing a highly enantioselective entry to chiral heterocyclicα-tertiary amines.

关 键 词：Pd(Ⅱ)-Catalysis Asymmetric addition Bisimidazoline ligand α-Tertiary amines ENANTIOSELECTIVITY 

分 类 号：O62[理学—有机化学]