Transition-metal and base-free ether synthesis via alcohol-participated yne-allylic substitution  

作　　者：Chao Xu Yingkun Luo Shengtong Niu Fan Gong Shouang Lan Benlong Luo Jinggong Liu Shuang Yang Xinqiang Fang 

机构地区：[1]College of Chemistry,Fuzhou University,Fuzhou 350116,China [2]State Key Laboratory of Structural Chemistry,And Key Laboratory of Coal to Ethylene Glycol and Its Related Technology,Center for Excellence in Molecular Synthesis,Fujian Institute of Research on the Structure of Matter,University of Chinese Academy of Sciences,Fuzhou 350100,China [3]Orthopedics Department,Guangdong Provincial Hospital of Traditional Chinese Medicine,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China [4]Pingxiang University,Pingxiang 337055,China

出　　处：《Green Synthesis and Catalysis》2024年第4期303-309,共7页绿色合成与催化（英文）

基　　金：Financial support was provided by NSFC(Nos.22071242 and 21871260);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000);Fujian Natural Science Foundation(Nos.2018J05035 and 2021J01522).

摘　　要：Ethers are among the most important chemicals in organic synthesis,the pharmaceutical industry,agrochemical production,and material science.C–O bond formation via substitution is one of the most widely used strategies for ether formation.However,known methods usually employ transition-metal and bases to facilitate the process.In this work,we describe the base-and transition-metal-free ether formation via alcohol and phenol-participated substitution.The protocol allows access to a large number of ethers with enyne functional moieties,and features mild reaction conditions,high efficiency,and good regio-and stereoselectivities.The reaction could be readily scaled up,and the products could be used in a range of further transformations.

关 键 词：Ether synthesis Yne-allylic substitution Transition-metal free Base free ALCOHOL 

分 类 号：O62[理学—有机化学]