Ni–Al Bimetal-Catalyzed Tertiary C(sp^(3))–H Activation for Dual C–H Annulation of Formamides with Alkynes  

作　　者：Yi Li Yu-Peng Liu Mengying Xu Weiwei Xu Feng-Ping Zhang Mengchun Ye 

机构地区：[1]State Key Laboratory of Elemento-Organic Chemistry,College of Chemistry,Haihe Laboratory of Sustainable Chemical Transformations,Frontiers Science Center for New Organic Matter,Nankai University,Tianjin 300071

出　　处：《CCS Chemistry》2024年第11期2671-2678,共8页中国化学会会刊（英文）

基　　金：the National Key R&D Program of China(grant no.2022YFA1504300);the National Natural Science Foundation of China(grant nos.22188101 and 22325103);the Haihe Laboratory of Sustainable Chemical Transformations and“Frontiers Science Center for New Organic Matter,”Nankai University(grant no.63181206);the Fundamental Research Funds for the Central Universities for financial support.

摘　　要：3d-Metal-catalyzed tertiary C(sp^(3))–H bond activation has been a formidable challenge.Herein,a tertiary C(sp^(3))–H bond is smoothly activated by Ni–Al bimetallic catalysts for dual C–H annulation of formamides with alkynes,delivering a series of δ-lactams with a quaternary carbon up to 98%yield.Various tertiary C(sp^(3))–H bonds such as noncyclic,monocyclic and bridged-ring tertiary C(sp^(3))–H bonds are all compatible with the reaction.

关 键 词：tertiary C(sp3)–H bond activation dual C–H annulation LACTAM BIMETAL nickel 

分 类 号：O62[理学—有机化学]